Josue D Gonzalez Murcia
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Explore the profile of Josue D Gonzalez Murcia including associated specialties, affiliations and a list of published articles.
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10
Citations
163
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Recent Articles
1.
Miller J, Brandon J, McKinnon L, Sabra H, Lucido C, Gonzalez Murcia J, et al.
bioRxiv
. 2025 Jan;
PMID: 39829933
Background: Synonymous variant () in the Paired Immunoglobulin-like Type 2 Receptor Alpha () gene was previously associated with decreased risk for Alzheimer's disease (AD) in genome-wide association studies, but its...
2.
Ferris E, Gonzalez Murcia J, Cristina Rodriguez A, Steinwand S, Stacher Horndli C, Traenkner D, et al.
bioRxiv
. 2024 Jul;
PMID: 38979381
Elucidating the genetic basis of mammalian metabolism could help define mechanisms central to health and disease. Here, we define conserved regulatory elements (CREs) and programs for mammalian metabolic control. We...
3.
Steinwand S, Stacher Horndli C, Ferris E, Emery J, Gonzalez Murcia J, Cristina Rodriguez A, et al.
bioRxiv
. 2024 Jul;
PMID: 38979203
Our study elucidates functional roles for conserved elements associated with the evolution of mammalian hibernation. Genomic analyses found topologically associated domains (TADs) that disproportionately accumulated convergent genomic changes in hibernators,...
4.
Lindsay H, Hendrix C, Gonzalez Murcia J, Haynie C, Weber K
Int J Mol Sci
. 2023 Nov;
24(22).
PMID: 38003682
Neuroinflammation is associated with several neurodegenerative disorders, including Alzheimer's disease (AD), Parkinson's disease (PD), and multiple sclerosis (MS). Neuroinflammation provides protection in acute situations but results in significant damage to...
5.
Gonzalez Murcia J, Weinert A, Tellez Freitas C, Arens D, Ferrel M, Grose J, et al.
Sci Rep
. 2020 May;
10(1):8019.
PMID: 32415244
A recent genome-wide association study (GWAS) of 59 cerebrospinal fluid (CSF) proteins with a connection to Alzheimer's disease (AD) demonstrated an association between increased levels of chemokine ligand 2 (CCL2)...
6.
Vance E, Gonzalez Murcia J, Miller J, Staley L, Crane P, Mukherjee S, et al.
Neurobiol Aging
. 2020 Mar;
89:142.e9-142.e12.
PMID: 32143980
Alzheimer's disease (AD) is the most common cause of dementia and, despite decades of effort, there is no effective treatment. In the last decade, many association studies have identified genetic...
7.
Patel D, Mez J, Vardarajan B, Staley L, Chung J, Zhang X, et al.
JAMA Netw Open
. 2019 Mar;
2(3):e191350.
PMID: 30924900
Importance: Some of the unexplained heritability of Alzheimer disease (AD) may be due to rare variants whose effects are not captured in genome-wide association studies because very large samples are...
8.
Ridge P, Karch C, Hsu S, Arano I, Teerlink C, Ebbert M, et al.
Genome Med
. 2018 Jan;
10(1):4.
PMID: 29329552
The original version of this article [1] unfortunately contained a typographical error. The 'Alzheimer's Disease Neuroimaging Initiative' was erroneously included as 'Alzheimer's Disease Neuroimaging Initative' in the author list of...
9.
Ridge P, Karch C, Hsu S, Arano I, Teerlink C, Ebbert M, et al.
Genome Med
. 2017 Nov;
9(1):100.
PMID: 29183403
Background: While age and the APOE ε4 allele are major risk factors for Alzheimer's disease (AD), a small percentage of individuals with these risk factors exhibit AD resilience by living...
10.
Wang L, Naj A, Graham R, Crane P, Kunkle B, Cruchaga C, et al.
JAMA Neurol
. 2014 Dec;
72(2):209-16.
PMID: 25531812
Importance: Recently, a rare variant in the amyloid precursor protein gene (APP) was described in a population from Iceland. This variant, in which alanine is replaced by threonine at position...