Joshy George
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Explore the profile of Joshy George including associated specialties, affiliations and a list of published articles.
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85
Citations
8345
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Recent Articles
11.
Woo X, Srivastava A, Mack P, Graber J, Sanderson B, Lloyd M, et al.
Cancer Res
. 2022 Sep;
82(22):4126-4138.
PMID: 36069866
Significance: Patient-derived xenografts of lung cancer retain key features observed in the originating patient tumors and show expected responses to treatment with standard-of-care agents, providing experimentally tractable and reproducible models...
12.
Martinek J, Lin J, Kim K, Wang V, Wu T, Chiorazzi M, et al.
Cell Rep Med
. 2022 May;
3(5):100621.
PMID: 35584631
Modulation of immune function at the tumor site could improve patient outcomes. Here, we analyze patient samples of metastatic melanoma, a tumor responsive to T cell-based therapies, and find that...
13.
Tang-Schomer M, Chandok H, Wu W, Lau C, Bookland M, George J
Transl Oncol
. 2022 Apr;
20:101407.
PMID: 35381525
Brain tumors are the leading cause of cancer-related deaths in children. Tailored therapies need preclinical brain tumor models representing a wide range of molecular subtypes. Here, we adapted a previously...
14.
Abdelfattah N, Kumar P, Wang C, Leu J, Flynn W, Gao R, et al.
Nat Commun
. 2022 Feb;
13(1):767.
PMID: 35140215
A major rate-limiting step in developing more effective immunotherapies for GBM is our inadequate understanding of the cellular complexity and the molecular heterogeneity of immune infiltrates in gliomas. Here, we...
15.
Ravanmehr V, Blau H, Cappelletti L, Fontana T, Carmody L, Coleman B, et al.
NAR Genom Bioinform
. 2021 Dec;
3(4):lqab113.
PMID: 34888523
Inhibiting protein kinases (PKs) that cause cancers has been an important topic in cancer therapy for years. So far, almost 8% of >530 PKs have been targeted by FDA-approved medications,...
16.
Geuther B, Chen M, Galante R, Han O, Lian J, George J, et al.
Sleep
. 2021 Oct;
45(2).
PMID: 34718812
Study Objectives: Sleep is an important biological process that is perturbed in numerous diseases, and assessment of its substages currently requires implantation of electrodes to carry out electroencephalogram/electromyogram (EEG/EMG) analysis....
17.
Liu Y, Lehar A, Rydzik R, Chandok H, Lee Y, Youngstrom D, et al.
Proc Natl Acad Sci U S A
. 2021 Aug;
118(33).
PMID: 34385332
Skeletal muscle and bone homeostasis are regulated by members of the myostatin/GDF-11/activin branch of the transforming growth factor-β superfamily, which share many regulatory components, including inhibitory extracellular binding proteins and...
18.
Yu C, Martinek J, Wu T, Kim K, George J, Ahmadzadeh E, et al.
J Exp Med
. 2021 Apr;
218(6).
PMID: 33857287
Metastasis of melanoma significantly worsens prognosis; thus, therapeutic interventions that prevent metastasis could improve patient outcomes. Here, we show using humanized mice that colonization of distant visceral organs with melanoma...
19.
Kassuhn W, Klein O, Darb-Esfahani S, Lammert H, Handzik S, Taube E, et al.
Cancers (Basel)
. 2021 Apr;
13(7).
PMID: 33806030
Despite the correlation of clinical outcome and molecular subtypes of high-grade serous ovarian cancer (HGSOC), contemporary gene expression signatures have not been implemented in clinical practice to stratify patients for...
20.
Busuttil R, George J, House C, Lade S, Mitchell C, Di Costanzo N, et al.
Gastric Cancer
. 2020 Dec;
24(3):589-601.
PMID: 33277667
Objective: Gastric cancer patients generally have a poor outcome, particularly those with advanced-stage disease which is defined by the increased invasion of cancer locally and is associated with higher metastatic...