Joshua R Leeman
Overview
Explore the profile of Joshua R Leeman including associated specialties, affiliations and a list of published articles.
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Articles
7
Citations
250
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0
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Recent Articles
1.
Bandarage U, Clark M, Perola E, Gao H, Jacobs M, Tsai A, et al.
ACS Med Chem Lett
. 2017 Feb;
8(2):261-265.
PMID: 28197323
JNJ-63623872 () is a first-in-class, orally bioavailable compound that offers significant potential for the treatment of pandemic and seasonal influenza. Early lead optimization efforts in our 7-azaindole series focused on...
2.
Farmer L, Clark M, Boyd M, Perola E, Jones S, Tsai A, et al.
ACS Med Chem Lett
. 2017 Feb;
8(2):256-260.
PMID: 28197322
In our efforts to develop novel small-molecule inhibitors for the treatment of influenza, we utilized molecular modeling and the X-ray crystal structure of the PB2 subunit of the influenza polymerase...
3.
Tsai A, McNeil C, Leeman J, Bennett H, Nti-Addae K, Huang C, et al.
Antimicrob Agents Chemother
. 2015 Jul;
59(10):6007-16.
PMID: 26169418
Through antigenic drift and shifts, influenza virus infections continue to be an annual cause of morbidity in healthy populations and of death among elderly and at-risk patients. The emergence of...
4.
Boyd M, Bandarage U, Bennett H, Byrn R, Davies I, Gu W, et al.
Bioorg Med Chem Lett
. 2015 Apr;
25(9):1990-4.
PMID: 25827523
VX-787 is a first in class, orally bioavailable compound that offers unparalleled potential for the treatment of pandemic and seasonal influenza. As a part of our routine SAR exploration, carboxylic...
5.
Byrn R, Jones S, Bennett H, Bral C, Clark M, Jacobs M, et al.
Antimicrob Agents Chemother
. 2014 Dec;
59(3):1569-82.
PMID: 25547360
VX-787 is a novel inhibitor of influenza virus replication that blocks the PB2 cap-snatching activity of the influenza viral polymerase complex. Viral genetics and X-ray crystallography studies provide support for...
6.
Clark M, Ledeboer M, Davies I, Byrn R, Jones S, Perola E, et al.
J Med Chem
. 2014 Jul;
57(15):6668-78.
PMID: 25019388
In our effort to develop agents for the treatment of influenza, a phenotypic screening approach utilizing a cell protection assay identified a series of azaindole based inhibitors of the cap-snatching...
7.
Leeman J, Gilmore T
Gene
. 2008 Aug;
423(2):97-107.
PMID: 18718859
Activation of transcription factor NF-kappaB can affect the expression of several hundred genes, many of which are involved in inflammation and immunity. The proper NF-kappaB transcriptional response is primarily regulated...