Joshua R Cook
Overview
Explore the profile of Joshua R Cook including associated specialties, affiliations and a list of published articles.
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Articles
19
Citations
3022
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Recent Articles
1.
Cook J, Bedeir N, Sone Z, Wattacheril J, Ginsberg H, Laferrere B
Diabetes
. 2024 Sep;
73(12):2003-2008.
PMID: 39264822
Article Highlights:
2.
Zhou Q, Yu L, Cook J, Qiang L, Sun L
Cell Metab
. 2023 Aug;
35(9):1661-1671.e6.
PMID: 37625407
Organisms must adapt to fluctuating nutrient availability to maintain energy homeostasis. Here, we term the capacity for such adaptation and restoration "metabolic elasticity" and model it through ad libitum-fasting-refeeding cycles....
3.
Cook J, Hawkins M, Pajvani U
Nat Metab
. 2023 Jul;
5(7):1101-1110.
PMID: 37460842
Metabolic dysfunction-associated fatty liver disease (MAFLD) is an increasingly prevalent fellow traveller with the insulin resistance that underlies type 2 diabetes mellitus. However, the mechanistic connection between MAFLD and impaired...
4.
Cook J, Kohan A, Haeusler R
J Lipid Res
. 2022 Sep;
63(11):100278.
PMID: 36100090
The small intestinal epithelium has classically been envisioned as a conduit for nutrient absorption, but appreciation is growing for a larger and more dynamic role for enterocytes in lipid metabolism....
5.
Izquierdo M, Shanmugarajah N, Lee S, Kraakman M, Westerterp M, Kitamoto T, et al.
J Clin Invest
. 2022 Feb;
132(7).
PMID: 35104242
Multiple beneficial cardiovascular effects of HDL depend on sphingosine-1-phosphate (S1P). S1P associates with HDL by binding to apolipoprotein M (ApoM). Insulin resistance is a major driver of dyslipidemia and cardiovascular...
6.
Cook J, Ausiello J
Rev Endocr Metab Disord
. 2021 Jul;
23(2):151-170.
PMID: 34195965
SARS-CoV-2, the virus responsible for COVID-19, uses angiotensin converting enzyme 2 (ACE2) as its primary cell-surface receptor. ACE2 is a key enzyme in the counter-regulatory pathway of the broader renin-angiotensin...
7.
Nalbandian A, Sehgal K, Gupta A, Madhavan M, McGroder C, Stevens J, et al.
Nat Med
. 2021 Mar;
27(4):601-615.
PMID: 33753937
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the pathogen responsible for the coronavirus disease 2019 (COVID-19) pandemic, which has resulted in global healthcare crises and strained health resources. As...
8.
Diamond J, Marboe C, Palmeri N, Cook J, Bijou R, Restaino S, et al.
Circ Heart Fail
. 2020 Sep;
13(12):e007204.
PMID: 32894982
No abstract available.
9.
Langlet F, Haeusler R, Linden D, Ericson E, Norris T, Johansson A, et al.
Cell
. 2017 Oct;
171(4):824-835.e18.
PMID: 29056338
Insulin resistance is a hallmark of diabetes and an unmet clinical need. Insulin inhibits hepatic glucose production and promotes lipogenesis by suppressing FOXO1-dependent activation of G6pase and inhibition of glucokinase,...
10.
Ren H, Cook J, Kon N, Accili D
Diabetes
. 2015 Jul;
64(11):3670-9.
PMID: 26180086
Hypothalamic neurons expressing agouti-related peptide (AgRP) regulate eating and glucose metabolism. Ablation of FOXO1 in AgRP neurons of mice results in reduced food intake, leanness, improved glucose homeostasis, and increased...