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Joshua Millstein

Explore the profile of Joshua Millstein including associated specialties, affiliations and a list of published articles. Areas
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Articles 72
Citations 1660
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Recent Articles
1.
Queen K, Barrett M, Millstein J
PeerJ . 2025 Jan; 13:e18580. PMID: 39886016
Motivation: As data sets increase in size and complexity with advancing technology, flexible and interpretable data reduction methods that quantify information preservation become increasingly important. Results: Super Partition is a...
2.
Arai H, Gandhi N, Battaglin F, Wang J, Algaze S, Jayachandran P, et al.
J Immunother Cancer . 2024 Nov; 12(11. PMID: 39500526
Background: In patients with colorectal cancer (CRC), the therapeutic effects of conventional immune checkpoint inhibitors targeting the adaptive immune system are largely limited to those with microsatellite instability-high tumors. Meanwhile,...
3.
Ashouri K, Wong A, Mittal P, Torres-Gonzalez L, Lo J, Soni S, et al.
Cancers (Basel) . 2024 Aug; 16(16). PMID: 39199569
Colorectal cancer (CRC) remains the second leading cause of cancer-related mortality worldwide. While immune checkpoint inhibitors have significantly improved patient outcomes, their effectiveness is mostly limited to tumors with microsatellite...
4.
Sharma N, Millstein J
Res Sq . 2024 Mar; PMID: 38496505
Background: In our recent work, we developed a novel dynamic programming algorithm to find optimal Bayesian networks (BNs) with parent set constraints. This 'generational orderings' based dynamic programming search algorithm...
5.
Arai H, Yang Y, Baca Y, Millstein J, Denda T, Ou F, et al.
Eur J Cancer . 2024 Feb; 201:113914. PMID: 38359495
Background: CDC37 is a key determinant of client kinase recruitment to the HSP90 chaperoning system. We hypothesized that kinase-specific dependency on CDC37 alters the efficacy of targeted therapies for metastatic...
6.
Battaglin F, Baca Y, Millstein J, Yang Y, Xiu J, Arai H, et al.
J Immunother Cancer . 2024 Jan; 12(1). PMID: 38212126
Background: The C-C motif chemokine receptor 5 (CCR5)/C-C motif chemokine ligand 5 (CCL5) axis plays a major role in colorectal cancer (CRC). We aimed to characterize the molecular features associated...
7.
Wang X, Salminen L, Petkus A, Driscoll I, Millstein J, Beavers D, et al.
medRxiv . 2023 Dec; PMID: 38077091
Background: Ambient air pollution exposures increase risk for Alzheimer's disease (AD) and related dementias, possibly due to structural changes in the medial temporal lobe (MTL). However, existing MRI studies examining...
8.
Petkus A, Salminen L, Wang X, Driscoll I, Millstein J, Beavers D, et al.
medRxiv . 2023 Dec; PMID: 38076972
Exposure to ambient air pollution, especially particulate matter with aerodynamic diameter <2.5 μm (PM) and nitrogen dioxide (NO), are environmental risk factors for Alzheimer's disease and related dementia. The medial...
9.
Chowdhury S, Gupta R, Millstein J, Lin K, Haridas V, Zeineddine M, et al.
JCO Precis Oncol . 2023 Jul; 7:e2200422. PMID: 37487150
Purpose: Activating mutations in , , and are known to cause resistance to anti-epidermal growth factor receptor (EGFR) therapy; however, only approximately 40% of patients with colorectal cancer (CRC) with...
10.
Queen K, Nguyen M, Gilliland F, Chun S, Raby B, Millstein J
Front Med (Lausanne) . 2023 Jun; 10:1118824. PMID: 37275375
Background: Existing module-based differential co-expression methods identify differences in gene-gene relationships across phenotype or exposure structures by testing for consistent changes in transcription abundance. Current methods only allow for assessment...