Joshua L Pollack
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Explore the profile of Joshua L Pollack including associated specialties, affiliations and a list of published articles.
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24
Citations
2899
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Recent Articles
1.
Juric V, Mayes E, Binnewies M, Lee T, Canaday P, Pollack J, et al.
Sci Transl Med
. 2023 Aug;
15(711):eadd9990.
PMID: 37647386
Myeloid cells in the tumor microenvironment (TME) can exist in immunosuppressive and immunostimulatory states that impede or promote antitumor immunity, respectively. Blocking suppressive myeloid cells or increasing stimulatory cells to...
2.
Mujal A, Combes A, Rao A, Binnewies M, Samad B, Tsui J, et al.
Cancer Immunol Res
. 2022 Feb;
10(4):403-419.
PMID: 35181780
The tumor immune microenvironment (TIME) is commonly infiltrated by diverse collections of myeloid cells. Yet, the complexity of myeloid-cell identity and plasticity has challenged efforts to define bona fide populations...
3.
Binnewies M, Pollack J, Rudolph J, Dash S, Abushawish M, Lee T, et al.
Cell Rep
. 2021 Oct;
37(3):109844.
PMID: 34686340
Converting checkpoint inhibitor (CPI)-resistant individuals to being responsive requires identifying suppressive mechanisms. We identify TREM2 tumor-associated macrophages (TAMs) as being correlated with exhausted CD8 tumor-infiltrating lymphocytes (TILs) in mouse syngeneic...
4.
Jahchan N, Mujal A, Pollack J, Binnewies M, Sriram V, Reyno L, et al.
Front Immunol
. 2019 Aug;
10:1611.
PMID: 31402908
The tumor microenvironment (TME) of diverse cancer types is often characterized by high levels of infiltrating myeloid cells including monocytes, macrophages, dendritic cells, and granulocytes. These cells perform a variety...
5.
Binnewies M, Mujal A, Pollack J, Combes A, Hardison E, Barry K, et al.
Cell
. 2019 Apr;
177(3):556-571.e16.
PMID: 30955881
Differentiation of proinflammatory CD4 conventional T cells (T) is critical for productive antitumor responses yet their elicitation remains poorly understood. We comprehensively characterized myeloid cells in tumor draining lymph nodes...
6.
Greenhalgh S, Matchett K, Taylor R, Huang K, Li J, Saeteurn K, et al.
Am J Pathol
. 2018 Nov;
189(2):258-271.
PMID: 30448409
Recent fate-mapping studies in mice have provided substantial evidence that mature adult hepatocytes are a major source of new hepatocytes after liver injury. In other systems, integrin αvβ8 has a...
7.
Miller C, Proekt I, von Moltke J, Wells K, Rajpurkar A, Wang H, et al.
Nature
. 2018 Jul;
559(7715):627-631.
PMID: 30022164
The thymus is responsible for generating a diverse yet self-tolerant pool of T cells. Although the thymic medulla consists mostly of developing and mature AIRE epithelial cells, recent evidence has...
8.
Nadjsombati M, McGinty J, Lyons-Cohen M, Jaffe J, DiPeso L, Schneider C, et al.
Immunity
. 2018 Jul;
49(1):33-41.e7.
PMID: 30021144
In the small intestine, type 2 responses are regulated by a signaling circuit that involves tuft cells and group 2 innate lymphoid cells (ILC2s). Here, we identified the microbial metabolite...
9.
Barry K, Hsu J, Broz M, Cueto F, Binnewies M, Combes A, et al.
Nat Med
. 2018 Jun;
24(8):1178-1191.
PMID: 29942093
Intratumoral stimulatory dendritic cells (SDCs) play an important role in stimulating cytotoxic T cells and driving immune responses against cancer. Understanding the mechanisms that regulate their abundance in the tumor...
10.
Bhakta N, Christenson S, Nerella S, Solberg O, Nguyen C, Choy D, et al.
Am J Respir Crit Care Med
. 2017 Oct;
197(3):313-324.
PMID: 29064281
Rationale: Quantification of type 2 inflammation provided a molecular basis for heterogeneity in asthma. Non-type 2 pathways that contribute to asthma pathogenesis are not well understood. Objectives: To identify dysregulated...