Joshua G Pierce
Overview
Explore the profile of Joshua G Pierce including associated specialties, affiliations and a list of published articles.
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Articles
52
Citations
440
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Recent Articles
1.
Chinthapatla R, Stephens J, Neumann-Rivera I, Henderson N, Nie M, Haynes H, et al.
BMC Pharmacol Toxicol
. 2024 Dec;
25(1):92.
PMID: 39639360
Background: Local drug presentation made possible by drug-eluting depots provides benefits for a vast array of diseases, including cancer, microbial infection, and wound healing. Drug-eluting depots provide sustained drug release...
2.
Alejandro Valdes-Pena M, Ratchford A, Nie M, Schnabel L, Pierce J
Chem Commun (Camb)
. 2024 Sep;
60(81):11540-11543.
PMID: 39311037
The absence of novel antibiotic classes, coupled with the rising threat of antibiotic persistence and resistance, is pushing the world perilously close to a new pre-antibiotic era. Over 35 000...
3.
Ho K, Pierce J
J Org Chem
. 2024 Sep;
89(18):13031-13037.
PMID: 39230008
An efficient method for the synthesis of spiropyrrolines from readily accessible α-formylamino ketones is reported. The method involves amide activation using TfO, followed by a formal [3 + 2]-cycloaddition of...
4.
Breunig J, Lin Y, Pierce J
Tetrahedron Lett
. 2024 Jul;
144.
PMID: 39006392
Thienamycin is a carbapenem antibiotic with potent activity against gram-negative and gram-positive bacteria. Due to its promising activity but lack of chemical stability, thienamycin serves as inspiration for new synthetic...
5.
Scull G, Aligwekwe A, Rey Y, Koch D, Nellenbach K, Sheridan A, et al.
J Biomed Mater Res A
. 2024 Jun;
112(12):2071-2085.
PMID: 38874363
Staphylococcus aureus skin and soft tissue infection is a common ailment placing a large burden upon global healthcare infrastructure. These bacteria are growing increasingly recalcitrant to frontline antimicrobial therapeutics like...
6.
Breunig J, Alejandro Valdes-Pena M, Ratchford A, Pierce J
ACS Bio Med Chem Au
. 2024 Apr;
4(2):95-99.
PMID: 38645927
New antimicrobial scaffolds are scarce, and there is a great need for the development of novel therapeutics. In this study, we report a convergent 9-step synthesis of leopolic acid A...
7.
Nie M, Alejandro Valdes-Pena M, Frohock B, Smits E, Daiker J, Gilbertie J, et al.
Bioorg Med Chem Lett
. 2024 Jan;
99:129609.
PMID: 38191097
Herein we report a new library of 2,3-pyrrolidinedione analogues that expands on our previous report on the antimicrobial studies of this heterocyclic scaffold. The novel 2,3-pyrrolidinediones reported herein have been...
8.
Guerra A, Pierce J
J Org Chem
. 2023 Dec;
89(1):810-814.
PMID: 38127085
We report a photoredox methodology for C(sp)-C(sp) coupling between α-bromoesters and triethylamine capable of accessing building blocks with handles for further functionalization. Mechanistic studies indicate the presence of a carbon...
9.
Qiu X, Pierce J
J Am Chem Soc
. 2022 Jul;
144(28):12638-12641.
PMID: 35786918
Indolizidine alkaloids have been the target of chemical and biological studies for decades, most recently highlighted by the isolation of the curvulamine and bipolamine polypyrrole-containing subclass. Herein we report a...
10.