Joshua E Mayfield
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Explore the profile of Joshua E Mayfield including associated specialties, affiliations and a list of published articles.
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22
Citations
359
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Recent Articles
1.
Zhang Q, Kim W, Panina S, Mayfield J, Portz B, Zhang Y
Nat Commun
. 2024 Sep;
15(1):7985.
PMID: 39266551
The C-terminal domain of RPB1 (CTD) orchestrates transcription by recruiting regulators to RNA Pol II upon phosphorylation. With CTD driving condensate formation on gene loci, the molecular mechanism behind how...
2.
Zhang Q, Kim W, Panina S, Mayfield J, Portz B, Zhang Y
bioRxiv
. 2024 Jan;
PMID: 38260389
The C-terminal domain of RPB1 (CTD) orchestrates transcription by recruiting regulators to RNA Pol II upon phosphorylation. Recent insights highlight the pivotal role of CTD in driving condensate formation on...
3.
Gu L, Zhu Y, Watari K, Lee M, Liu J, Perez S, et al.
Cell Metab
. 2023 Apr;
35(6):1009-1021.e9.
PMID: 37084733
Insulin inhibits gluconeogenesis and stimulates glucose conversion to glycogen and lipids. How these activities are coordinated to prevent hypoglycemia and hepatosteatosis is unclear. Fructose-1,6-bisphosphatase (FBP1) is rate controlling for gluconeogenesis....
4.
Mayfield J, Dixon J
Curr Opin Chem Biol
. 2023 Mar;
74:102279.
PMID: 36966700
Eukaryotes depend upon the proper localization, accumulation, and release of intracellular Ca2+. This is regulated through specialized cellular compartments, signaling pathways, and Ca2+-binding proteins and channels. Cytosolic and extracellular signaling...
5.
Rios J, Denton K, Russell J, Kozlitina J, Ferreira C, Lewanda A, et al.
J Bone Miner Res
. 2021 Apr;
36(8):1548-1565.
PMID: 33905568
Proper embryonic and postnatal skeletal development require coordination of myriad complex molecular mechanisms. Disruption of these processes, through genetic mutation, contributes to variation in skeletal development. We developed a high-throughput...
6.
Worby C, Mayfield J, Pollak A, Dixon J, Banerjee S
J Biol Chem
. 2021 Mar;
296:100267.
PMID: 33759783
The study of extracellular phosphorylation was initiated in late 19th century when the secreted milk protein, casein, and egg-yolk protein, phosvitin, were shown to be phosphorylated. However, it took more...
7.
Mayfield J, Irani S, Zhang Y
Bio Protoc
. 2021 Mar;
10(12):e3648.
PMID: 33659319
Eukaryotic RNA polymerase II transcribes all protein-coding mRNAs and is highly regulated. A key mechanism directing RNA polymerase II and facilitating the co-transcriptional processing of mRNAs is the phosphorylation of...
8.
Gong S, Kirmizialtin S, Chang A, Mayfield J, Zhang Y, Johnson K
J Biol Chem
. 2020 Dec;
296:100184.
PMID: 33310704
Magnesium ions play a critical role in catalysis by many enzymes and contribute to the fidelity of DNA polymerases through a two-metal ion mechanism. However, specificity is a kinetic phenomenon...
9.
Venkat Ramani M, Escobar E, Irani S, Mayfield J, Moreno R, Butalewicz J, et al.
ACS Chem Biol
. 2020 Jun;
15(8):2259-2272.
PMID: 32568517
The phosphorylation states of RNA polymerase II coordinate the process of eukaryotic transcription by recruitment of transcription regulators. The individual residues of the repetitive heptad of the C-terminal domain (CTD)...
10.
Banerjee S, Wei T, Wang J, Lee J, Gutierrez H, Chapman O, et al.
Proc Natl Acad Sci U S A
. 2019 Nov;
116(49):24881-24891.
PMID: 31754034
Dependence on the 26S proteasome is an Achilles' heel for triple-negative breast cancer (TNBC) and multiple myeloma (MM). The therapeutic proteasome inhibitor, bortezomib, successfully targets MM but often leads to...