Joshua D Chandler
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Explore the profile of Joshua D Chandler including associated specialties, affiliations and a list of published articles.
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44
Citations
785
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Recent Articles
1.
Avila A, Lewandowski A, Li Y, Gui J, Lee K, Yang Z, et al.
Proc Natl Acad Sci U S A
. 2025 Jan;
122(4):e2421178122.
PMID: 39847335
To regulate brain function, peripheral compounds must traverse the blood-brain barrier (BBB), an interface between the brain and the circulatory system. To determine whether specific transport mechanisms are relevant for...
2.
Zaveri S, Stecenko A, Hunt W, Goss A, Sharma P, Hartman T, et al.
BMJ Open
. 2024 Dec;
14(12):e092503.
PMID: 39725418
Introduction: People with cystic fibrosis (PwCF) are at high risk for developing cystic fibrosis (CF)-related diabetes (CFRD), which worsens morbidity and mortality. Although the pathological events leading to the development...
3.
Cui G, Moustafa D, Zhao S, Cegla A, Lyles J, Goldberg J, et al.
Am J Physiol Lung Cell Mol Physiol
. 2024 Jul;
327(4):L473-L486.
PMID: 39010826
Cystic fibrosis-related diabetes (CFRD), the most common comorbidity in cystic fibrosis (CF), leads to increased mortality by accelerating the decline in lung function. Tg transgenic mice overexpressing the epithelial sodium...
4.
Ashtiwi N, Kim S, Chandler J, Rada B
Free Radic Biol Med
. 2024 Apr;
219:104-111.
PMID: 38608822
Hypothiocyanous acid (HOSCN) is an endogenous oxidant produced by peroxidase oxidation of thiocyanate (SCN), an ubiquitous sulfur-containing pseudohalide synthesized from cyanide. HOSCN serves as a potent microbicidal agent against pathogenic...
5.
Horati H, Margaroli C, Chandler J, Kilgore M, Manai B, Andrinopoulou E, et al.
J Cyst Fibros
. 2024 Jan;
23(3):450-456.
PMID: 38246828
Introduction: Inflammation appears early in cystic fibrosis (CF) pathogenesis, with specific elevated inflammatory markers in bronchoalveolar lavage fluid (BALF) correlating with structural lung disease. Our aim was to identify markers...
6.
Kopp B, Ross S, Bojja D, Guglani L, Chandler J, Tirouvanziam R, et al.
J Cyst Fibros
. 2023 Nov;
23(2):219-225.
PMID: 37977937
Background: Detecting airway inflammation non-invasively in infants with cystic fibrosis (CF) is difficult. We hypothesized that markers of inflammation in CF [IL-1β, IL-6, IL-8, IL-10, IL-17A, neutrophil elastase (NE) and...
7.
Cottrill K, Chandler J, Kobara S, Stephenson S, Mohammad A, Tidwell M, et al.
J Allergy Clin Immunol Glob
. 2023 Aug;
2(3).
PMID: 37609569
Background: Asthma exacerbations are highly prevalent in children, but only a few studies have examined the biologic mechanisms underlying exacerbations in this population. Objective: High-resolution metabolomics analyses were performed to...
8.
Kim S, Shapiro J, Cottrill K, Collins G, Shanthikumar S, Rao P, et al.
Free Radic Biol Med
. 2023 Jun;
206:180-190.
PMID: 37356776
Myeloperoxidase (MPO) is released by neutrophils in inflamed tissues. MPO oxidizes chloride, bromide, and thiocyanate to produce hypochlorous acid (HOCl), hypobromous acid (HOBr), and hypothiocyanous acid (HOSCN), respectively. These oxidants...
9.
Chen J, Li S, Silva G, Chandler J, Prausnitz M, Guglani L
J Cyst Fibros
. 2023 May;
23(1):112-119.
PMID: 37236899
Background: The sweat test using pilocarpine iontophoresis remains the gold standard for diagnosing cystic fibrosis, but access and reliability are limited by specialized equipment and insufficient sweat volume collected from...
10.
Geitgey D, Lee M, Cottrill K, Jaffe M, Pilcher W, Bhasin S, et al.
J Natl Cancer Inst Monogr
. 2023 May;
2023(61):12-29.
PMID: 37139973
The obesity pandemic currently affects more than 70 million Americans and more than 650 million individuals worldwide. In addition to increasing susceptibility to pathogenic infections (eg, SARS-CoV-2), obesity promotes the...