Joshua D Chandler
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Explore the profile of Joshua D Chandler including associated specialties, affiliations and a list of published articles.
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44
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Recent Articles
11.
Smith M, Hu X, Jarrell Z, He X, Orr M, Fernandes J, et al.
Adv Redox Res
. 2023 Apr;
7.
PMID: 37034445
Cadmium (Cd) is a toxic environmental metal that interacts with selenium (Se) and contributes to many lung diseases. Humans have widespread exposures to Cd through diet and cigarette smoking, and...
12.
Druzak S, Iffrig E, Roberts B, Zhang T, Fibben K, Sakurai Y, et al.
Nat Commun
. 2023 Apr;
14(1):1638.
PMID: 37015925
The pathogenesis of multi-organ dysfunction associated with severe acute SARS-CoV-2 infection remains poorly understood. Endothelial damage and microvascular thrombosis have been identified as drivers of COVID-19 severity, yet the mechanisms...
13.
Giacalone V, Cammarata-Mouchtouris A, Moncada-Giraldo D, Shenoy S, Ponder L, Gergely T, et al.
Immunohorizons
. 2022 Nov;
6(11):768-778.
PMID: 36445361
Juvenile idiopathic arthritis (JIA) is an inflammatory rheumatic disorder. Polymorphonuclear neutrophils (PMNs) are present in JIA synovial fluid (SF), but with variable frequency. SF PMNs in JIA were previously shown...
14.
Eddins D, Yang J, Kosters A, Giacalone V, Pechuan-Jorge X, Chandler J, et al.
Blood Adv
. 2022 Nov;
7(5):778-799.
PMID: 36399523
Troubling disparities in COVID-19-associated mortality emerged early, with nearly 70% of deaths confined to Black/African American (AA) patients in some areas. However, targeted studies on this vulnerable population are scarce....
15.
Cottrill K, Stephenson S, Mohammad A, Kim S, McCarty N, Kamaleswaran R, et al.
J Allergy Clin Immunol
. 2022 Sep;
151(1):118-127.e10.
PMID: 36096204
Background: The asthma of some children remains poorly controlled, with recurrent exacerbations despite treatment with inhaled corticosteroids. Aside from prior exacerbations, there are currently no reliable predictors of exacerbation-prone asthma...
16.
Margaroli C, Horati H, Garratt L, Giacalone V, Schofield C, Dittrich A, et al.
J Cyst Fibros
. 2022 Jun;
21(6):967-976.
PMID: 35732550
Background: Macrophages are the major resident immune cells in human airways coordinating responses to infection and injury. In cystic fibrosis (CF), neutrophils are recruited to the airways shortly after birth,...
17.
Chandler J, Esther Jr C
Curr Opin Pharmacol
. 2022 Jun;
65:102238.
PMID: 35649321
While discovery metabolomic studies have identified many potential biomarkers of cystic fibrosis (CF) airways disease, relatively few have been validated. We review the recent literature to identify the most promising...
18.
Giacalone V, Moncada-Giraldo D, Margaroli C, Brown M, Silva G, Chandler J, et al.
Pediatr Pulmonol
. 2022 May;
57(9):2189-2198.
PMID: 35637404
Background: In this pilot study, we investigated whether induced sputum (IS) could serve as a viable alternative to bronchoalveolar lavage (BAL) and yield robust inflammatory biomarkers in toddlers with cystic...
19.
Eddins D, Bassit L, Chandler J, Haddad N, Musall K, Yang J, et al.
Immunohorizons
. 2022 Feb;
6(2):144-155.
PMID: 35173021
Due to the severity of COVID-19 disease, the U.S. Centers for Disease Control and Prevention and World Health Organization recommend that manipulation of active viral cultures of SARS-CoV-2 and respiratory...
20.
Sarr D, Gingerich A, Asthiwi N, Almutairi F, Sautto G, Ecker J, et al.
Proc Natl Acad Sci U S A
. 2021 Jun;
118(26).
PMID: 34168077
Dual oxidase 1 (DUOX1) is an NADPH oxidase that is highly expre-ssed in respiratory epithelial cells and produces HO in the airway lumen. While a line of prior in vitro...