Joshua C Randall
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Explore the profile of Joshua C Randall including associated specialties, affiliations and a list of published articles.
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16
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10394
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Recent Articles
1.
Nicholls S, Clare A, Randall J
Bioinformatics
. 2016 May;
32(13):2047-9.
PMID: 27153673
Unlabelled: : We present Goldilocks: a Python package providing functionality for collecting summary statistics, identifying shifts in variation, discovering outlier regions and locating and extracting interesting regions from one or...
2.
Locke A, Kahali B, Berndt S, Justice A, Pers T, Day F, et al.
Nature
. 2015 Feb;
518(7538):197-206.
PMID: 25673413
Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index...
3.
Shungin D, Winkler T, Croteau-Chonka D, Ferreira T, Locke A, Magi R, et al.
Nature
. 2015 Feb;
518(7538):187-196.
PMID: 25673412
Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat...
4.
Rahmioglu N, Macgregor S, Drong A, Hedman A, Harris H, Randall J, et al.
Hum Mol Genet
. 2014 Oct;
24(4):1185-99.
PMID: 25296917
Endometriosis is a chronic inflammatory condition in women that results in pelvic pain and subfertility, and has been associated with decreased body mass index (BMI). Genetic variants contributing to the...
5.
Wood A, Esko T, Yang J, Vedantam S, Pers T, Gustafsson S, et al.
Nat Genet
. 2014 Oct;
46(11):1173-86.
PMID: 25282103
Using genome-wide data from 253,288 individuals, we identified 697 variants at genome-wide significance that together explained one-fifth of the heritability for adult height. By testing different numbers of variants in...
6.
Winkler T, Day F, Croteau-Chonka D, Wood A, Locke A, Magi R, et al.
Nat Protoc
. 2014 Apr;
9(5):1192-212.
PMID: 24762786
Rigorous organization and quality control (QC) are necessary to facilitate successful genome-wide association meta-analyses (GWAMAs) of statistics aggregated across multiple genome-wide association studies. This protocol provides guidelines for (i) organizational...
7.
Randall J, Winkler T, Kutalik Z, Berndt S, Jackson A, Monda K, et al.
PLoS Genet
. 2013 Jun;
9(6):e1003500.
PMID: 23754948
Given the anthropometric differences between men and women and previous evidence of sex-difference in genetic effects, we conducted a genome-wide search for sexually dimorphic associations with height, weight, body mass...
8.
Berndt S, Gustafsson S, Magi R, Ganna A, Wheeler E, Feitosa M, et al.
Nat Genet
. 2013 Apr;
45(5):501-12.
PMID: 23563607
Approaches exploiting trait distribution extremes may be used to identify loci associated with common traits, but it is unknown whether these loci are generalizable to the broader population. In a...
9.
Voight B, Kang H, Ding J, Palmer C, Sidore C, Chines P, et al.
PLoS Genet
. 2012 Aug;
8(8):e1002793.
PMID: 22876189
Genome-wide association studies have identified hundreds of loci for type 2 diabetes, coronary artery disease and myocardial infarction, as well as for related traits such as body mass index, glucose...
10.
Speliotes E, Willer C, Berndt S, Monda K, Thorleifsson G, Jackson A, et al.
Nat Genet
. 2010 Oct;
42(11):937-48.
PMID: 20935630
Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain largely elusive. To identify genetic loci for obesity susceptibility, we examined associations between body mass index and...