Anne U Jackson
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Explore the profile of Anne U Jackson including associated specialties, affiliations and a list of published articles.
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139
Citations
34082
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Recent Articles
1.
Brotman S, El-Sayed Moustafa J, Guan L, Broadaway K, Wang D, Jackson A, et al.
Nat Genet
. 2025 Jan;
57(1):180-192.
PMID: 39747594
Complete characterization of the genetic effects on gene expression is needed to elucidate tissue biology and the etiology of complex traits. In the present study, we analyzed 2,344 subcutaneous adipose...
2.
Willems S, Ng N, Fernandez J, Fine R, Wheeler E, Wessel J, et al.
Wellcome Open Res
. 2024 Sep;
8():483.
PMID: 39280063
Background: Genome-wide association studies for glycemic traits have identified hundreds of loci associated with these biomarkers of glucose homeostasis. Despite this success, the challenge remains to link variant associations to...
3.
Varshney A, Manickam N, Orchard P, Tovar A, Ventresca C, Zhang Z, et al.
bioRxiv
. 2024 Jan;
PMID: 38168419
Skeletal muscle, the largest human organ by weight, is relevant in several polygenic metabolic traits and diseases including type 2 diabetes (T2D). Identifying genetic mechanisms underlying these traits requires pinpointing...
4.
Brotman S, El-Sayed Moustafa J, Guan L, Broadaway K, Wang D, Jackson A, et al.
bioRxiv
. 2023 Nov;
PMID: 37961277
Complete characterization of the genetic effects on gene expression is needed to elucidate tissue biology and the etiology of complex traits. Here, we analyzed 2,344 subcutaneous adipose tissue samples and...
5.
Lagou V, Jiang L, Ulrich A, Zudina L, Gonzalez K, Balkhiyarova Z, et al.
Nat Genet
. 2023 Sep;
55(9):1448-1461.
PMID: 37679419
Conventional measurements of fasting and postprandial blood glucose levels investigated in genome-wide association studies (GWAS) cannot capture the effects of DNA variability on 'around the clock' glucoregulatory processes. Here we...
6.
van de Vegte Y, Eppinga R, van der Ende M, Hagemeijer Y, Mahendran Y, Salfati E, et al.
Nat Commun
. 2023 Aug;
14(1):4646.
PMID: 37532724
Resting heart rate is associated with cardiovascular diseases and mortality in observational and Mendelian randomization studies. The aims of this study are to extend the number of resting heart rate...
7.
Yin X, Li J, Bose D, Okamoto J, Kwon A, Jackson A, et al.
medRxiv
. 2023 Jul;
PMID: 37425837
Metabolites are small molecules that are useful for estimating disease risk and elucidating disease biology. Nevertheless, their causal effects on human diseases have not been evaluated comprehensively. We performed two-sample...
8.
Williamson A, Norris D, Yin X, Broadaway K, Moxley A, Vadlamudi S, et al.
Nat Genet
. 2023 Jun;
55(6):973-983.
PMID: 37291194
Distinct tissue-specific mechanisms mediate insulin action in fasting and postprandial states. Previous genetic studies have largely focused on insulin resistance in the fasting state, where hepatic insulin action dominates. Here...
9.
Graham S, Clarke S, Wu K, Kanoni S, Zajac G, Ramdas S, et al.
Nature
. 2023 May;
618(7965):E19-E20.
PMID: 37237109
No abstract available.
10.
Broadaway K, Yin X, Williamson A, Parsons V, Wilson E, Moxley A, et al.
Am J Hum Genet
. 2023 Jan;
110(2):284-299.
PMID: 36693378
Insulin secretion is critical for glucose homeostasis, and increased levels of the precursor proinsulin relative to insulin indicate pancreatic islet beta-cell stress and insufficient insulin secretory capacity in the setting...