Joshua B Rubin
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Explore the profile of Joshua B Rubin including associated specialties, affiliations and a list of published articles.
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141
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6888
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Recent Articles
1.
Robust Cluster Prediction Across Data Types Validates Association of Sex and Therapy Response in GBM
Gibbs D, Cioffi G, Aguilar B, Waite K, Pan E, Mandel J, et al.
Cancers (Basel)
. 2025 Feb;
17(3).
PMID: 39941811
Background: Previous studies have described sex-specific patient subtyping in glioblastoma. The cluster labels associated with these "legacy data" were used to train a predictive model capable of recapitulating this clustering...
2.
Gonzalez-Aponte M, Damato A, Simon T, Aripova N, Darby F, Jeon M, et al.
Cancer Cell
. 2024 Dec;
43(1):144-160.e7.
PMID: 39672168
Glioblastoma (GBM) is the most common primary malignant brain tumor in adults with a poor prognosis despite aggressive therapy. Here, we hypothesized that daily host signaling regulates tumor growth and...
3.
Rubin J, Abou-Antoun T, Ippolito J, Llaci L, Marquez C, Wong J, et al.
J Clin Invest
. 2024 Jul;
134(13).
PMID: 38949020
Cancer risk is modulated by hereditary and somatic mutations, exposures, age, sex, and gender. The mechanisms by which sex and gender work alone and in combination with other cancer risk...
4.
Huang J, Campian J, DeWees T, Skrott Z, Mistrik M, Johanns T, et al.
Int J Radiat Oncol Biol Phys
. 2024 May;
120(3):738-749.
PMID: 38768767
Purpose: This phase 1/2 study aimed to evaluate the safety and preliminary efficacy of combining disulfiram and copper (DSF/Cu) with radiation therapy (RT) and temozolomide (TMZ) in patients with newly...
5.
Gonzalez-Aponte M, Damato A, Simon T, Aripova N, Darby F, Rubin J, et al.
bioRxiv
. 2024 May;
PMID: 38766060
Glioblastoma (GBM) is the most common primary brain tumor in adults with a poor prognosis despite aggressive therapy. A recent, retrospective clinical study found that administering Temozolomide in the morning...
6.
Treating sex and gender differences as a continuous variable can improve precision cancer treatments
Yang W, Rubin J
Biol Sex Differ
. 2024 Apr;
15(1):35.
PMID: 38622740
Background: The significant sex and gender differences that exist in cancer mechanisms, incidence, and survival, have yet to impact clinical practice. One barrier to translation is that cancer phenotypes cannot...
7.
Gonzalez-Aponte M, Damato A, Trebucq L, Simon T, Cardenas-Garcia S, Cho K, et al.
J Neurooncol
. 2024 Jan;
166(3):419-430.
PMID: 38277015
Background: Glioblastoma (GBM) is the most common primary brain tumor in adults. Despite extensive research and clinical trials, median survival post-treatment remains at 15 months. Thus, all opportunities to optimize...
8.
Bond K, Curtin L, Ranjbar S, Afshari A, Hu L, Rubin J, et al.
Front Oncol
. 2023 Oct;
13:1185738.
PMID: 37849813
Imaging is central to the clinical surveillance of brain tumors yet it provides limited insight into a tumor's underlying biology. Machine learning and other mathematical modeling approaches can leverage paired...
9.
Cognition and Brain System Segregation in Pediatric Brain Tumor Patients Treated with Proton Therapy
Dowling A, Seitzman B, Mitchell T, Olufawo M, Dierker D, Anandarajah H, et al.
Int J Part Ther
. 2023 Oct;
10(1):32-42.
PMID: 37823016
Purpose: Pediatric brain tumor patients often experience significant cognitive sequelae. Resting-state functional MRI (rsfMRI) provides a measure of brain network organization, and we hypothesize that pediatric brain tumor patients treated...
10.
Seitzman B, Reynoso F, Mitchell T, Bice A, Jarang A, Wang X, et al.
Geroscience
. 2023 Sep;
46(1):543-562.
PMID: 37749370
Cognitive dysfunction following radiotherapy (RT) is one of the most common complications associated with RT delivered to the brain, but the precise mechanisms behind this dysfunction are not well understood,...