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David H Gutmann

Explore the profile of David H Gutmann including associated specialties, affiliations and a list of published articles. Areas
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Articles 415
Citations 18485
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Recent Articles
1.
Ng J, Chen Y, Akinwe T, Heins H, Mehinovic E, Chang Y, et al.
Cell Genom . 2025 Mar; :100807. PMID: 40073865
Prior studies examining genomic variants suggest that some proteins contribute to both neurodevelopmental disorders (NDDs) and cancer. While there are several potential etiologies, here, we hypothesize that missense variation in...
2.
Chatterjee J, Qi X, Mu R, Li X, Eligator T, Ouyang M, et al.
Neuro Oncol . 2025 Jan; PMID: 39868555
Background: The intestinal microbiota regulates normal brain physiology and the pathogenesis of several neurological disorders. While prior studies suggested that this regulation operates through immune cells, the underlying mechanisms remain...
3.
Gupta A, Hillis E, Oh I, Morris S, Abrams Z, Foraker R, et al.
JAMIA Open . 2025 Jan; 8(1):ooae157. PMID: 39845289
Objective: Dimensionality reduction techniques aim to enhance the performance of machine learning (ML) models by reducing noise and mitigating overfitting. We sought to compare the effect of different dimensionality reduction...
4.
Katz J, Ratnam S, Listernick R, Habiby R, Gutmann D
J Pediatr . 2024 Dec; 278:114440. PMID: 39674537
This multi-institutional, descriptive study of 19 children with neurofibromatosis 1 examines the link between optic pathway gliomas (OPGs) and central precocious puberty (CPP). We report that CPP can arise without...
5.
Barakat R, Chatterjee J, Mu R, Qi X, Gu X, Smirnov I, et al.
Nat Commun . 2024 Nov; 15(1):10312. PMID: 39609412
In solid cancers, T cells typically function as cytotoxic effectors to limit tumor growth, prompting therapies that capitalize upon this antineoplastic property (immune checkpoint inhibition; ICI). Unfortunately, ICI treatments have...
6.
Tarnawsky T, Oh I, Hillis E, Gupta A, Gutmann D
J Pediatr . 2024 Nov; 277:114413. PMID: 39557385
There are few centers with combined pediatric and adult neurofibromatosis 1 practices and transition of care programming. Using an electronic health records-based approach, we found an early death peak in...
7.
Hwang W, Perrault E, Birbrair A, Mattson B, Gutmann D, Mabbott D, et al.
Cancer Cell . 2024 Oct; 43(1):1-5. PMID: 39423816
Cancer neuroscience is a rapidly growing multidisciplinary field that conceptualizes tumors as tissues fully integrated into the nervous system. Recognizing the complexity and challenges in this field is of fundamental...
8.
Gutmann D, Boehm J, Karlsson E, Padron E, Seshadri M, Wallis D, et al.
J Natl Cancer Inst . 2024 Oct; PMID: 39383197
A new era of cancer management is underway in which treatments are being developed for the entire continuum of the disease process. The availability of genetically engineered and naturally occurring...
9.
Chan A, Zhang K, Martin G, Bano S, Chatterjee J, Mahto S, et al.
Neuro Oncol . 2024 Jul; 26(12):2339-2351. PMID: 39023130
Background: Pediatric low-grade glioma incidence has been rising in the United States, mirroring the rising rates of pediatric and maternal obesity. Recently, children of obese mothers were demonstrated to develop...
10.
Thumu S, Jain M, Soman S, Das S, Verma V, Nandi A, et al.
Elife . 2024 Jul; 13. PMID: 38949864
No abstract available.