Joshua A Jadwin
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Explore the profile of Joshua A Jadwin including associated specialties, affiliations and a list of published articles.
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10
Citations
311
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Recent Articles
1.
Jadwin J, Curran T, Lafontaine A, White F, Mayer B
J Biol Chem
. 2017 Nov;
293(2):623-637.
PMID: 29162725
Phosphotyrosine (pTyr)-dependent signaling is critical for many cellular processes. It is highly dynamic, as signal output depends not only on phosphorylation and dephosphorylation rates but also on the rates of...
2.
Jadwin J
Methods Mol Biol
. 2017 Jan;
1555:477-492.
PMID: 28092051
Over the last two decades there has been a significant effort in the field to characterize the phosphosite binding specificities of SH2 domains with the goal of deciphering the pY...
3.
Jadwin J, Oh D, Curran T, Ogiue-Ikeda M, Jia L, White F, et al.
Elife
. 2016 Apr;
5:e11835.
PMID: 27071344
While the affinities and specificities of SH2 domain-phosphotyrosine interactions have been well characterized, spatio-temporal changes in phosphosite availability in response to signals, and their impact on recruitment of SH2-containing proteins...
4.
Jadwin J, Mayer B, Machida K
Methods Mol Biol
. 2015 Jun;
1312:379-98.
PMID: 26044019
Far-western blotting is a convenient method to characterize protein-protein interactions, in which protein samples of interest are immobilized on a membrane and then probed with a non-antibody protein. In contrast...
5.
Oh D, Ogiue-Ikeda M, Jadwin J, Machida K, Mayer B, Yu J
Proc Natl Acad Sci U S A
. 2012 Aug;
109(35):14024-9.
PMID: 22886086
Receptor tyrosine kinases (RTKs) control a host of biological functions by phosphorylating tyrosine residues of intracellular proteins upon extracellular ligand binding. The phosphotyrosines (p-Tyr) then recruit a subset of ∼100...
6.
Jadwin J, Ogiue-Ikeda M, Machida K
FEBS Lett
. 2012 Jun;
586(17):2586-96.
PMID: 22710164
The ability of modular protein domains to independently fold and bind short peptide ligands both in vivo and in vitro has allowed a significant number of protein-protein interaction studies to...
7.
Szczepaniak R, Nellissery J, Jadwin J, Makhov A, Kosinski A, Conway J, et al.
J Virol
. 2011 Jun;
85(17):8625-34.
PMID: 21697480
Disulfide bonds reportedly stabilize the capsids of several viruses, including papillomavirus, polyomavirus, and simian virus 40, and have been detected in herpes simplex virus (HSV) capsids. In this study, we...
8.
Sette P, Jadwin J, Dussupt V, Bello N, Bouamr F
J Virol
. 2010 Jun;
84(16):8181-92.
PMID: 20519395
The p6 region of HIV-1 Gag contains two late (L) domains, PTAP and LYPX(n)L, that bind Tsg101 and Alix, respectively. Interactions with these two cellular proteins recruit members of the...
9.
Jadwin J, Rudd V, Sette P, Challa S, Bouamr F
J Virol
. 2009 Oct;
84(2):704-15.
PMID: 19864377
Moloney murine leukemia virus (MoMLV) Gag utilizes its late (L) domain motif PPPY to bind members of the Nedd4-like ubiquitin ligase family. These interactions recruit components of the cell's budding...
10.
Dussupt V, Javid M, Abou-Jaoude G, Jadwin J, de la Cruz J, Nagashima K, et al.
PLoS Pathog
. 2009 Mar;
5(3):e1000339.
PMID: 19282983
HIV-1 release is mediated through two motifs in the p6 region of Gag, PTAP and LYPX(n)L, which recruit cellular proteins Tsg101 and Alix, respectively. The Nucleocapsid region of Gag (NC),...