Josh Gregorio
Overview
Explore the profile of Josh Gregorio including associated specialties, affiliations and a list of published articles.
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Articles
15
Citations
3095
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0
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Recent Articles
1.
Meller S, Di Domizio J, Voo K, Friedrich H, Chamilos G, Ganguly D, et al.
Nat Immunol
. 2015 Jul;
16(9):970-9.
PMID: 26168081
Interleukin 17-producing helper T cells (T(H)17 cells) have a major role in protection against infections and in mediating autoimmune diseases, yet the mechanisms involved are incompletely understood. We found that...
2.
Chamilos G, Gregorio J, Meller S, Lande R, Kontoyiannis D, Modlin R, et al.
Blood
. 2012 Aug;
120(18):3699-707.
PMID: 22927244
The intracellular location of nucleic acid sensors prevents recognition of extracellular self-DNA released by dying cells. However, on forming a complex with the endogenous antimicrobial peptide LL37, extracellular DNA is...
3.
Conrad C, Gregorio J, Wang Y, Ito T, Meller S, Hanabuchi S, et al.
Cancer Res
. 2012 Aug;
72(20):5240-9.
PMID: 22850422
Epithelial ovarian cancer (EOC) is the fifth most common cause of cancer death among women. Despite its immunogenicity, effective antitumor responses are limited, due, in part, to the presence of...
4.
Lande R, Ganguly D, Facchinetti V, Frasca L, Conrad C, Gregorio J, et al.
Sci Transl Med
. 2011 Mar;
3(73):73ra19.
PMID: 21389263
Systemic lupus erythematosus (SLE) is a severe and incurable autoimmune disease characterized by chronic activation of plasmacytoid dendritic cells (pDCs) and production of autoantibodies against nuclear self-antigens by hyperreactive B...
5.
Gregorio J, Meller S, Conrad C, Di Nardo A, Homey B, Lauerma A, et al.
J Exp Med
. 2010 Dec;
207(13):2921-30.
PMID: 21115688
Plasmacytoid dendritic cells (pDCs) are specialized type I interferon (IFN-α/β)-producing cells that express intracellular toll-like receptor (TLR) 7 and TLR9 and recognize viral nucleic acids in the context of infections....
6.
Chamilos G, Ganguly D, Lande R, Gregorio J, Meller S, Goldman W, et al.
PLoS One
. 2010 Oct;
5(9):e12955.
PMID: 20886035
Interleukin-17 (IL-17) producing T helper cells (T(H)-17) comprise a newly recognized T cell subset with an emerging role in adaptive immunity to a variety of fungi. Whether different airborne fungi...
7.
Ganguly D, Chamilos G, Lande R, Gregorio J, Meller S, Facchinetti V, et al.
J Exp Med
. 2009 Aug;
206(9):1983-94.
PMID: 19703986
Dendritic cell (DC) responses to extracellular self-DNA and self-RNA are prevented by the endosomal seclusion of nucleic acid-recognizing Toll-like receptors (TLRs). In psoriasis, however, plasmacytoid DCs (pDCs) sense self-DNA that...
8.
Lande R, Gregorio J, Facchinetti V, Chatterjee B, Wang Y, Homey B, et al.
Nature
. 2007 Sep;
449(7162):564-9.
PMID: 17873860
Plasmacytoid dendritic cells (pDCs) sense viral and microbial DNA through endosomal Toll-like receptors to produce type 1 interferons. pDCs do not normally respond to self-DNA, but this restriction seems to...
9.
Ito T, Yang M, Wang Y, Lande R, Gregorio J, Perng O, et al.
J Exp Med
. 2007 Jan;
204(1):105-15.
PMID: 17200410
Although there is evidence for distinct roles of myeloid dendritic cells (DCs [mDCs]) and plasmacytoid pre-DCs (pDCs) in regulating T cell-mediated adaptive immunity, the concept of functional DC subsets has...
10.
Barrat F, Meeker T, Gregorio J, Chan J, Uematsu S, Akira S, et al.
J Exp Med
. 2005 Oct;
202(8):1131-9.
PMID: 16230478
Raised serum levels of interferon (IFN)-alpha have been observed in systemic lupus erythematosus (SLE) patients, and these levels are correlated with both disease activity and severity. The origin of this...