Joseph R Warner
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Explore the profile of Joseph R Warner including associated specialties, affiliations and a list of published articles.
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10
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255
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Recent Articles
1.
Mansell T, Warner J, Gill R
Methods Mol Biol
. 2013 Feb;
985:223-46.
PMID: 23417807
Recent advances in homologous recombination in Escherichia coli have enabled improved genome engineering by multiplex recombineering. In this chapter, we present trackable multiplex recombineering (TRMR), a method for gene-trait mapping...
2.
Woodruff L, May B, Warner J, Gill R
Biotechnol Bioeng
. 2013 Jan;
110(5):1520-6.
PMID: 23322646
In the genome-engineering era, it is increasingly important that researchers have access to a common set of platform strains that can serve as debugged production chassis and the basis for...
3.
Sandoval N, Kim J, Glebes T, Reeder P, Aucoin H, Warner J, et al.
Proc Natl Acad Sci U S A
. 2012 Jun;
109(26):10540-5.
PMID: 22689973
We describe a directed genome-engineering approach that combines genome-wide methods for mapping genes to traits [Warner JR, Reeder PJ, Karimpour-Fard A, Woodruff LBA, Gill RT (2010) Nat Biotechnol 28:856-862] with...
4.
Warner J, Reeder P, Karimpour-Fard A, Woodruff L, Gill R
Nat Biotechnol
. 2010 Jul;
28(8):856-62.
PMID: 20639866
A fundamental goal in biotechnology and biology is the development of approaches to better understand the genetic basis of traits. Here we report a versatile method, trackable multiplex recombineering (TRMR),...
5.
Warner J, Patnaik R, Gill R
Curr Opin Microbiol
. 2009 May;
12(3):223-30.
PMID: 19467921
Progress in the field of strain engineering is being made by identifying the genetic basis of complex phenotypes, engineering new phenotypes, and combining beneficial phenotypes in industrial hosts. Advances in...
6.
Warner J, Behlen L, Copley S
Biochemistry
. 2008 Feb;
47(10):3258-65.
PMID: 18275157
Tetrachlorohydroquinone (TCHQ) dehalogenase is profoundly inhibited by its aromatic substrates, TCHQ and trichlorohydroquinone (TriCHQ). Surprisingly, mutations that change Ile12 to either Ser or Ala give an enzyme that shows no...
7.
Warner J, Copley S
Biochemistry
. 2007 Oct;
46(45):13211-22.
PMID: 17956123
Tetrachlorohydroquinone dehalogenase catalyzes two successive reductive dehalogenation reactions in the pathway for degradation of pentachlorophenol in the soil bacterium Sphingobium chlorophenolicum. We have used pre-steady-state kinetic methods to probe both...
8.
Warner J, Copley S
Biochemistry
. 2007 Mar;
46(14):4438-47.
PMID: 17355122
Tetrachlorohydroquinone (TCHQ) dehalogenase catalyzes the conversion of TCHQ to 2,6-dichlorohydroquinone during degradation of pentachlorophenol by Sphingobium chlorophenolicum. TCHQ dehalogenase is a member of the glutathione S-transferase superfamily. Members of this...
9.
Warner J, Lawson S, Copley S
Biochemistry
. 2005 Jul;
44(30):10360-8.
PMID: 16042413
Tetrachlorohydroquinone dehalogenase catalyzes the reductive dehalogenation of tetrachloro- and trichlorohydroquinone to give 2,6-dichlorohydroquinone in the pathway for degradation of pentachlorophenol by Sphingobium chlorophenolicum. Previous work has suggested that this enzyme...
10.
Dai M, Rogers J, Warner J, Copley S
J Bacteriol
. 2002 Dec;
185(1):302-10.
PMID: 12486067
The first step in the pentachlorophenol (PCP) degradation pathway in Sphingobium chlorophenolicum has been believed for more than a decade to be conversion of PCP to tetrachlorohydroquinone. We show here...