Joseph Pearlberg
Overview
Explore the profile of Joseph Pearlberg including associated specialties, affiliations and a list of published articles.
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Articles
14
Citations
979
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0
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Recent Articles
1.
Chandra A, Jackson R, Karnal A, Pearlberg J
Contemp Clin Trials Commun
. 2020 Jun;
18:100559.
PMID: 32490279
No abstract available.
2.
Abramson V, Supko J, Ballinger T, Cleary J, Hilton J, Tolaney S, et al.
Clin Cancer Res
. 2016 Dec;
23(14):3520-3528.
PMID: 28031425
This phase Ib study was designed to determine the MTD, safety, preliminary efficacy, and pharmacokinetics of the HER3 (ErbB3) mAb SAR256212 in combination with the oral PI3K inhibitor SAR245408 for...
3.
Liu J, Ray-Coquard I, Selle F, Poveda A, Cibula D, Hirte H, et al.
J Clin Oncol
. 2016 Dec;
34(36):4345-4353.
PMID: 27998236
Purpose Seribantumab is a fully human immunoglobulin G2 monoclonal antibody that binds to human epidermal growth factor receptor (HER) 3 (ErbB3), blocking heregulin (HRG) -mediated ErbB3 signaling and inducing ErbB3...
4.
den Hollander M, Bensch F, Glaudemans A, Oude Munnink T, Enting R, den Dunnen W, et al.
J Nucl Med
. 2015 Jul;
56(9):1310-4.
PMID: 26135113
Unlabelled: Transforming growth factor-β (TGF-β) signaling is involved in glioma development. The monoclonal antibody fresolimumab (GC1008) can neutralize all mammalian isoforms of TGF-β, and tumor uptake can be visualized and...
5.
Gonzalez-Malerva L, Park J, Zou L, Hu Y, Moradpour Z, Pearlberg J, et al.
Proc Natl Acad Sci U S A
. 2011 Jan;
108(5):2058-63.
PMID: 21233418
Resistance to tamoxifen in breast cancer patients is a serious therapeutic problem and major efforts are underway to understand underlying mechanisms. Resistance can be either intrinsic or acquired. We derived...
6.
Foley J, Maeder M, Pearlberg J, Joung J, Peterson R, Yeh J
Nat Protoc
. 2009 Dec;
4(12):1855-67.
PMID: 20010934
Zebrafish mutants have traditionally been obtained by using random mutagenesis or retroviral insertions, methods that cannot be targeted to a specific gene and require laborious gene mapping and sequencing. Recently,...
7.
Baldwin A, Li W, Grace M, Pearlberg J, Harlow E, Munger K, et al.
Proc Natl Acad Sci U S A
. 2008 Oct;
105(43):16478-83.
PMID: 18948598
Human papillomavirus (HPV) oncoproteins subvert cellular signaling pathways, including kinase pathways, during the carcinogenic process. To identify kinases targeted by the HPV16 E7 oncoprotein, shRNA kinase screens were performed in...
8.
Grueneberg D, Li W, Davies J, Sawyer J, Pearlberg J, Harlow E
Proc Natl Acad Sci U S A
. 2008 Oct;
105(43):16490-5.
PMID: 18948597
Functional differences among human cells have been difficult to identify by standard biochemical methods. Loss-of-function shRNA screens provide an unbiased method to compare protein requirements across cell lines. In previous...
9.
Grueneberg D, Degot S, Pearlberg J, Li W, Davies J, Baldwin A, et al.
Proc Natl Acad Sci U S A
. 2008 Oct;
105(43):16472-7.
PMID: 18948591
shRNA loss-of-function screens were used to identify kinases that were rate-limiting for promoting cell proliferation and survival. Here, we study the differences in kinase requirements among various human cells, including...
10.
Maeder M, Thibodeau-Beganny S, Osiak A, Wright D, Anthony R, Eichtinger M, et al.
Mol Cell
. 2008 Jul;
31(2):294-301.
PMID: 18657511
Custom-made zinc-finger nucleases (ZFNs) can induce targeted genome modifications with high efficiency in cell types including Drosophila, C. elegans, plants, and humans. A bottleneck in the application of ZFN technology...