Joseph K Rathkey
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Explore the profile of Joseph K Rathkey including associated specialties, affiliations and a list of published articles.
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9
Citations
682
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Recent Articles
1.
Karmakar M, Minns M, Greenberg E, Diaz-Aponte J, Pestonjamasp K, Johnson J, et al.
Nat Commun
. 2020 May;
11(1):2212.
PMID: 32371889
Gasdermin-D (GSDMD) in inflammasome-activated macrophages is cleaved by caspase-1 to generate N-GSDMD fragments. N-GSDMD then oligomerizes in the plasma membrane (PM) to form pores that increase membrane permeability, leading to...
2.
Rathkey J, Xiao T, Abbott D
J Biol Chem
. 2020 Jan;
295(10):3228-3238.
PMID: 31988247
Exomic studies have demonstrated that innate immune genes exhibit an even higher degree of variation than the majority of other gene families. However, the phenotypic implications of this genetic variation...
3.
Rathkey J, Zhao J, Liu Z, Chen Y, Yang J, Kondolf H, et al.
Sci Immunol
. 2018 Aug;
3(26).
PMID: 30143556
Dysregulation of inflammatory cell death is a key driver of many inflammatory diseases. Pyroptosis, a highly inflammatory form of cell death, uses intracellularly generated pores to disrupt electrolyte homeostasis and...
4.
Chirieleison S, Rathkey J, Abbott D
Sci Signal
. 2018 Jul;
11(539).
PMID: 30018081
The mammalian IAPs, X-linked inhibitor of apoptosis protein (XIAP) and cellular inhibitor of apoptosis protein 1 and 2 (cIAP1 and cIAP2), play pivotal roles in innate immune signaling and inflammatory...
5.
Yang J, Liu Z, Wang C, Yang R, Rathkey J, Pinkard O, et al.
Proc Natl Acad Sci U S A
. 2018 Jun;
115(26):6792-6797.
PMID: 29891674
The inflammasomes are signaling platforms that promote the activation of inflammatory caspases such as caspases-1, -4, -5, and -11. Recent studies identified gasdermin D (GSDMD) as an effector for pyroptosis...
6.
Liu Z, Wang C, Rathkey J, Yang J, Dubyak G, Abbott D, et al.
Structure
. 2018 Mar;
26(5):778-784.e3.
PMID: 29576317
Pyroptosis is an inflammatory form of programmed cell death that plays important roles in immune protection against infections and in inflammatory disorders. Gasdermin D (GSDMD) is an executor of pyroptosis...
7.
Rathkey J, Benson B, Chirieleison S, Yang J, Xiao T, Dubyak G, et al.
J Biol Chem
. 2017 Jul;
292(35):14649-14658.
PMID: 28726636
Pyroptosis is a form of cell death important in defenses against pathogens that can also result in a potent and sometimes pathological inflammatory response. During pyroptosis, GSDMD (gasdermin D), the...
8.
Chirieleison S, Marsh R, Kumar P, Rathkey J, Dubyak G, Abbott D
J Biol Chem
. 2017 Apr;
292(23):9666-9679.
PMID: 28404814
The X-linked inhibitor of apoptosis (XIAP) protein has been identified as a key genetic driver of two distinct inflammatory disorders, X-linked lymphoproliferative syndrome 2 (XLP-2) and very-early-onset inflammatory bowel disease...
9.
Rathkey J, Wall-Scheffler C
Am J Phys Anthropol
. 2017 Feb;
163(1):85-93.
PMID: 28195301
Objectives: The purpose of this article is to test whether people choose to behave in a manner that reduces the amount of energy they use to travel a given distance....