Joseph Ipe
Overview
Explore the profile of Joseph Ipe including associated specialties, affiliations and a list of published articles.
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Articles
15
Citations
140
Followers
0
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Recent Articles
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2.
Powell N, Liang T, Ipe J, Cao S, Skaar T, Desta Z, et al.
Nat Commun
. 2023 Mar;
14(1):1474.
PMID: 36927865
Polypharmacy is common in patients with nonalcoholic fatty liver disease (NAFLD) and previous reports suggest that NAFLD is associated with altered drug disposition. This study aims to determine if patients...
3.
Powell N, Silvola R, Howard J, Badve S, Skaar T, Ipe J
Cancer Rep (Hoboken)
. 2022 Jul;
6(1):e1686.
PMID: 35906899
Background: Chemotherapeutic drug concentrations vary across different regions of tumors and this is thought to be involved in development of chemotherapy resistance. Insufficient drug delivery to some regions of the...
4.
Onuoha C, Ipe J, Simpson E, Liu Y, Skaar T, Kreutz R
Clin Transl Sci
. 2022 Jun;
15(8):1946-1958.
PMID: 35643946
MicroRNAs (miRNAs) are small RNAs integral in the regulation of gene expression. Analysis of circulating miRNA levels may identify patients with coronary artery disease (CAD) at risk for recurrent myocardial...
5.
Powell N, Zhao H, Ipe J, Liu Y, Skaar T
Clin Pharmacol Ther
. 2021 Jul;
110(4):1106-1118.
PMID: 34314509
MiRNAs regulate the expression of hepatic genes involved in pharmacokinetics and pharmacodynamics. Genetic variants affecting miRNA binding (mirSNPs) have been associated with altered drug response, but previously used methods to...
6.
Tillman E, Ipe J, Weaver K, Skaar T, Rowan C, Slaven J
Clin Transl Sci
. 2021 Jan;
14(1):310-316.
PMID: 33448674
Children admitted to the pediatric intensive care unit (PICU) often require multiple medications to achieve comfort and sedation. Although starting doses are available, these medications are typically titrated to the...
7.
Ipe J, Li R, Metzger I, Lu J, Gufford B, Desta Z, et al.
Clin Pharmacol Ther
. 2020 Aug;
109(2):485-493.
PMID: 32772362
The CYP2B6 gene is highly polymorphic and its activity shows wide interindividual variability. However, substantial variability in CYP2B6 activity remains unexplained by the known CYP2B6 genetic variations. Circulating, cell-free micro...
8.
Lin H, Hargreaves K, Li R, Reiter J, Wang Y, Mort M, et al.
Genome Biol
. 2019 Nov;
20(1):254.
PMID: 31779641
Single nucleotide variants (SNVs) in intronic regions have yet to be systematically investigated for their disease-causing potential. Using known pathogenic and neutral intronic SNVs (iSNVs) as training data, we develop...
9.
Rao X, Thapa K, Chen A, Lin H, Gao H, Reiter J, et al.
Mol Psychiatry
. 2019 Sep;
26(4):1142-1151.
PMID: 31477794
Genome-wide association studies (GWAS) of complex traits, such as alcohol use disorders (AUD), usually identify variants in non-coding regions and cannot by themselves distinguish whether the associated variants are functional...
10.
Kanuri S, Ipe J, Kassab K, Gao H, Liu Y, Skaar T, et al.
Atherosclerosis
. 2018 Oct;
278:232-239.
PMID: 30336307
Background And Aims: Variation in micro-RNA (miRNA) levels in blood has been associated with alterations of physiological functions of the cardiovascular system. Circulating miRNA have the potential to become reliable...