Joseph Holoshitz
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Explore the profile of Joseph Holoshitz including associated specialties, affiliations and a list of published articles.
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34
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Recent Articles
11.
Gehlot P, Volk S, Rios H, Jepsen K, Holoshitz J
RMD Open
. 2016 Dec;
2(2):e000349.
PMID: 27933212
Objective: Shared epitope (SE)-coding alleles are associated with bone erosion in several diseases, including rheumatoid arthritis (RA) and periodontal disease (PD), but the underlying mechanism is unknown. We have recently...
12.
van Drongelen V, Holoshitz J
Front Biosci (Landmark Ed)
. 2016 Nov;
22(5):909-919.
PMID: 27814654
Human leukocyte antigens (HLA) have been extensively studied as being antigen presenting receptors, but many aspects of their function remain elusive, especially their association with various autoimmune diseases. Here we...
13.
Chukkapalli S, Rivera-Kweh M, Gehlot P, Velsko I, Bhattacharyya I, Calise S, et al.
Arthritis Res Ther
. 2016 Jul;
18(1):161.
PMID: 27405639
Background: It has been previously hypothesized that oral microbes may be an etiological link between rheumatoid arthritis (RA) and periodontal disease. However, the mechanistic basis of this association is incompletely...
14.
Ling S, Liu Y, Fu J, Colletta A, Gilon C, Holoshitz J
Arthritis Rheumatol
. 2015 Apr;
67(8):2061-70.
PMID: 25892196
Objective: The mechanisms underlying bone damage in rheumatoid arthritis (RA) are incompletely understood. We recently identified the shared epitope (SE), an HLA-DRB1-coded 5-amino acid sequence motif carried by the majority...
15.
Holoshitz J
Discov Med
. 2013 Sep;
16(87):93-101.
PMID: 23998445
Dozens of human diseases and health traits are significantly more common among individuals carrying particular human leukocyte antigens (HLA) alleles. The underlying mechanism of this phenomenon, commonly referred to as...
16.
Fu J, Ling S, Liu Y, Yang J, Naveh S, Hannah M, et al.
J Immunol
. 2013 Jul;
191(5):2096-103.
PMID: 23885107
We have recently proposed that the shared epitope (SE) may contribute to rheumatoid arthritis pathogenesis by acting as a ligand that activates proarthritogenic signal transduction events. To examine this hypothesis,...
17.
Ling S, Cline E, Haug T, Fox D, Holoshitz J
Arthritis Rheum
. 2012 Dec;
65(3):618-26.
PMID: 23233327
Objective: Citrullinated proteins are immunogenic in rheumatoid arthritis (RA), particularly in patients who carry shared epitope (SE)-coding HLA-DRB1 alleles. The mechanism underlying this association is unknown. We have previously identified...
18.
Holoshitz J, Liu Y, Fu J, Joseph J, Ling S, Colletta A, et al.
J Immunol
. 2012 Nov;
190(1):48-57.
PMID: 23180817
Particular alleles of HLA contribute to disease susceptibility and severity in many autoimmune conditions, but the mechanisms underlying these associations are often unknown. In this study, we demonstrate that the...
19.
Naveh S, Tal-Gan Y, Ling S, Hoffman A, Holoshitz J, Gilon C
Bioorg Med Chem Lett
. 2011 Nov;
22(1):493-6.
PMID: 22113111
Rheumatoid arthritis (RA) is a common human leukocyte antigen-associated disease. Most RA patients have a five-residue sequence motif called the shared epitope (SE) in the DRβ-chain of the HLA-DRB1 protein....
20.
de Almeida D, Holoshitz J
Self Nonself
. 2011 Jul;
2(1):43-48.
PMID: 21776334
Half a century after the major histocompatibility complex (MHC) was discovered, its functional roles in health and disease remain poorly understood. Many hallmarks of the MHC, including its unusual evolution,...