Joseph Holoshitz
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Explore the profile of Joseph Holoshitz including associated specialties, affiliations and a list of published articles.
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34
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664
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Recent Articles
21.
de Almeida D, Ling S, Holoshitz J
FEBS Lett
. 2011 Mar;
585(23):3619-26.
PMID: 21420962
The shared epitope (SE) - an HLA-DRB1-encoded 5-amino acid sequence motif carried by the vast majority of rheumatoid arthritis (RA) patients - is a risk factor for severe disease. The...
22.
Holoshitz J, de Almeida D, Ling S
Ann N Y Acad Sci
. 2010 Oct;
1209:91-8.
PMID: 20958321
Calreticulin (CRT) plays a role in the clearance of dying cells and has been implicated in autoimmunity. Recent evidence indicates that cell surface CRT (csCRT) acts as a signal transducing...
23.
Ling S, Cheng A, Pumpens P, Michalak M, Holoshitz J
PLoS One
. 2010 Jul;
5(7):e11703.
PMID: 20661469
Background: The rheumatoid arthritis (RA) shared epitope (SE), a major risk factor for severe disease, is a five amino acid motif in the third allelic hypervariable region of the HLA-DRbeta...
24.
de Almeida D, Ling S, Pi X, Hartmann-Scruggs A, Pumpens P, Holoshitz J
J Immunol
. 2010 Jul;
185(3):1927-34.
PMID: 20592276
Rheumatoid arthritis (RA) is closely associated with HLA-DRB1 alleles that code a five-amino acid sequence motif in positions 70-74 of the HLA-DRbeta-chain, called the shared epitope (SE). The mechanistic basis...
25.
Holoshitz J
Curr Opin Rheumatol
. 2010 Jan;
22(3):293-8.
PMID: 20061955
Purpose Of Review: To update progress made between December 2008 and November 2009 on the role of the rheumatoid arthritis (RA)-shared epitope in the cause and pathogenesis of RA. Recent...
26.
Ling S, Pi X, Holoshitz J
J Immunol
. 2007 Oct;
179(9):6359-67.
PMID: 17947714
The shared epitope (SE), carried by the vast majority of rheumatoid arthritis patients, is a 5-aa sequence motif in the third allelic hypervariable region of the HLA-DRbeta chain. We have...
27.
Holoshitz J, Ling S
Ann N Y Acad Sci
. 2007 Oct;
1110:73-83.
PMID: 17911422
Many immune-mediated diseases are associated with particular MHC class I or class II alleles. In rheumatoid arthritis (RA-shared), the vast majority of patients possess HLA-DRB1 alleles encoding a shared epitope,...
28.
Ling S, Li Z, Borschukova O, Xiao L, Pumpens P, Holoshitz J
Arthritis Res Ther
. 2007 Jan;
9(1):R5.
PMID: 17254342
We have recently demonstrated that the rheumatoid arthritis (RA) shared epitope (SE) acts as a ligand that triggers nitric oxide (NO) signaling in opposite cells. Given the known pro-oxidative effect...
29.
Tan S, Xiao L, Pi X, Holoshitz J
Front Biosci
. 2006 Nov;
12:1651-60.
PMID: 17127411
Sphingosine 1-phosphate (S1P) is a pleiotropic bioactive lipid that transmits potent signals through a family of G protein coupled receptors with resultant anti-apoptotic and pro-angiogenic effects. We have recently reported...
30.
Ling S, Lai A, Borschukova O, Pumpens P, Holoshitz J
Arthritis Rheum
. 2006 Nov;
54(11):3423-32.
PMID: 17075829
Objective: Susceptibility to rheumatoid arthritis (RA) is closely associated with HLA-DRB1 alleles encoding a shared epitope (SE) in positions 70-74 of the HLA-DRbeta chain. The mechanistic basis for this association...