Joseph E Wedekind
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Explore the profile of Joseph E Wedekind including associated specialties, affiliations and a list of published articles.
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73
Citations
1494
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Recent Articles
1.
Iannuzzelli J, Bonn R, Hong A, Anitha A, Jenkins J, Wedekind J, et al.
Chem Sci
. 2024 Nov;
15(46):19520-19533.
PMID: 39568906
RNA provides the genetic blueprint for many pathogenic viruses, including SARS-CoV-2. The propensity of RNA to fold into specific tertiary structures enables the biomolecular recognition of cavities and crevices suited...
2.
Kiliushik D, Goenner C, Law M, Schroeder G, Srivastava Y, Jenkins J, et al.
J Biol Chem
. 2024 Nov;
300(12):107951.
PMID: 39486689
Riboswitches sense specific cellular metabolites, leading to messenger RNA conformational changes that regulate downstream genes. Here, we review the three known prequeosine (preQ) riboswitch classes, which encompass five gene-regulatory motifs...
3.
Srivastava Y, Akinyemi O, Rohe T, Pritchett E, Baker C, Sharma A, et al.
Nucleic Acids Res
. 2024 Oct;
52(21):13152-13173.
PMID: 39413212
Riboswitches are structured RNAs that sense small molecules to control expression. Prequeuosine1 (preQ1)-sensing riboswitches comprise three classes (I, II and III) that adopt distinct folds. Despite this difference, class II...
4.
Srivastava Y, Blau M, Jenkins J, Wedekind J
Biochemistry
. 2023 Nov;
62(23):3396-3410.
PMID: 37947391
Bacterial riboswitches are structured RNAs that bind small metabolites to control downstream gene expression. Two riboswitch classes have been reported to sense nicotinamide adenine dinucleotide (NAD), which plays a key...
5.
Schroeder G, Kiliushik D, Jenkins J, Wedekind J
J Biol Chem
. 2023 Sep;
299(10):105208.
PMID: 37660906
Riboswitches are small noncoding RNAs found primarily in the 5' leader regions of bacterial messenger RNAs where they regulate expression of downstream genes in response to binding one or more...
6.
Kretsch R, Andersen E, Bujnicki J, Chiu W, Das R, Luo B, et al.
Proteins
. 2023 Jul;
91(12):1600-1615.
PMID: 37466021
The first RNA category of the Critical Assessment of Techniques for Structure Prediction competition was only made possible because of the scientists who provided experimental structures to challenge the predictors....
7.
8.
Schroeder G, Akinyemi O, Malik J, Focht C, Pritchett E, Baker C, et al.
Nucleic Acids Res
. 2023 Feb;
51(5):2464-2484.
PMID: 36762498
Riboswitches regulate downstream gene expression by binding cellular metabolites. Regulation of translation initiation by riboswitches is posited to occur by metabolite-mediated sequestration of the Shine-Dalgarno sequence (SDS), causing bypass by...
9.
Cavender C, Schroeder G, Mathews D, Wedekind J
Methods Mol Biol
. 2022 Oct;
2568:53-73.
PMID: 36227562
Isothermal titration calorimetry (ITC) is a powerful biophysical tool to characterize energetic profiles of biomacromolecular interactions without any alteration of the underlying chemical structures. In this protocol, we describe procedures...
10.
Schroeder G, Cavender C, Blau M, Jenkins J, Mathews D, Wedekind J
Nat Commun
. 2022 Jan;
13(1):199.
PMID: 35017488
Riboswitches are structured non-coding RNAs often located upstream of essential genes in bacterial messenger RNAs. Such RNAs regulate expression of downstream genes by recognizing a specific cellular effector. Although nearly...