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» Authors » Joseph E Dinchuk

Joseph E Dinchuk

Explore the profile of Joseph E Dinchuk including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 7
Citations 178
Followers 0
Related Specialties
Pharmacology
General Medicine
Biochemistry
Top 10 Co-Authors
Paul A Friedman
Ricardo M Attar
Eric J Wexler
Sean Kim
Mujing Yan
George C Psaltis
Nicola T Neff
Joseph C Arezzo
Huaping Tang
Andrew A Stern
Published In
J Biol Chem
Drug Metab Dispos
PLoS One
J Pharmacol Exp Ther
Endocrinology
Affiliations
Soon will be listed here.
Recent Articles
1.
P2Y6 receptor potentiates pro-inflammatory responses in macrophages and exhibits differential roles in atherosclerotic lesion development
Garcia R, Yan M, Search D, Zhang R, Carson N, Ryan C, et al.
PLoS One . 2014 Nov; 9(10):e111385. PMID: 25360548
Background: P2Y(6), a purinergic receptor for UDP, is enriched in atherosclerotic lesions and is implicated in pro-inflammatory responses of key vascular cell types and macrophages. Evidence for its involvement in...
2.
Drug safety is a barrier to the discovery and development of new androgen receptor antagonists
Foster W, Car B, Shi H, Levesque P, Obermeier M, Gan J, et al.
Prostate . 2010 Sep; 71(5):480-8. PMID: 20878947
Background: Androgen receptor (AR) antagonists are part of the standard of care for prostate cancer. Despite the almost inevitable development of resistance in prostate tumors to AR antagonists, no new...
3.
Insulin receptor (IR) pathway hyperactivity in IGF-IR null cells and suppression of downstream growth signaling using the dual IGF-IR/IR inhibitor, BMS-754807
Dinchuk J, Cao C, Huang F, Reeves K, Wang J, Myers F, et al.
Endocrinology . 2010 Jul; 151(9):4123-32. PMID: 20610571
The biology of IGF-IR/IR signaling was studied in normal mouse embryonic fibroblasts (MEFs) that were either wild type (wt), heterozygous (het), or null for the IGF-IR. The ability of IGF-I,...
4.
Evaluation of cynomolgus monkey pregnane X receptor, primary hepatocyte, and in vivo pharmacokinetic changes in predicting human CYP3A4 induction
Kim S, Dinchuk J, Anthony M, Orcutt T, Zoeckler M, Sauer M, et al.
Drug Metab Dispos . 2009 Oct; 38(1):16-24. PMID: 19833845
Monkeys have been proposed as an animal model to predict the magnitude of human clinical drug-drug interactions caused by CYP3A4 enzyme induction. To evaluate whether the cynomolgus monkey can be...
5.
COX-3: in the wrong frame in mind
Dinchuk J, Liu R, Trzaskos J
Immunol Lett . 2003 Feb; 86(1):121. PMID: 12600754
No abstract available.
6.
Antisense oligonucleotides selectively regulate aspartyl beta-hydroxylase and its truncated protein isoform in vitro but distribute poorly into A549 tumors in vivo
Ho S, Scully M, Krauthauser C, Wexler E, Stow M, Dinchuk J, et al.
J Pharmacol Exp Ther . 2002 Jul; 302(2):795-803. PMID: 12130746
Alternative splicing of the human beta-aspartyl (asparaginyl) hydroxylase (BAH) gene results in the expression of humbug, a truncated form of BAH that lacks the catalytic domain of the enzyme. Overexpression...
7.
Absence of post-translational aspartyl beta-hydroxylation of epidermal growth factor domains in mice leads to developmental defects and an increased incidence of intestinal neoplasia
Dinchuk J, Focht R, Kelley J, Henderson N, Zolotarjova N, Wynn R, et al.
J Biol Chem . 2002 Jan; 277(15):12970-7. PMID: 11773073
The BAH genomic locus encodes three distinct proteins: junctin, humbug, and BAH. All three proteins share common exons, but differ significantly based upon the use of alternative terminal exons. The...