Joseph E Brayden
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Explore the profile of Joseph E Brayden including associated specialties, affiliations and a list of published articles.
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35
Citations
2491
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Recent Articles
1.
Syed A, Koide M, Brayden J, Wellman G
J Cereb Blood Flow Metab
. 2017 Dec;
39(4):670-679.
PMID: 29260608
Activation of ATP-sensitive potassium (K) channels in arterial smooth muscle (ASM) contributes to vasodilation evoked by a variety of endogenous and exogenous compounds. Although controversial, activation of K channels by...
2.
Longden T, Dabertrand F, Koide M, Gonzales A, Tykocki N, Brayden J, et al.
Nat Neurosci
. 2017 Mar;
20(5):717-726.
PMID: 28319610
Blood flow into the brain is dynamically regulated to satisfy the changing metabolic requirements of neurons, but how this is accomplished has remained unclear. Here we demonstrate a central role...
3.
Moon T, Tykocki N, Sheehe J, Osborne B, Tegge W, Brayden J, et al.
Chem Biol
. 2015 Dec;
22(12):1653-61.
PMID: 26687482
PKG is a multifaceted signaling molecule and potential pharmaceutical target due to its role in smooth muscle function. A helix identified in the structure of the regulatory domain of PKG...
4.
Li Y, Brayden J
J Cereb Blood Flow Metab
. 2015 Dec;
37(1):140-152.
PMID: 26661251
Cerebral arterioles contribute critically to regulation of local and global blood flow within the brain. Dysfunction of these blood vessels is implicated in numerous cardiovascular diseases. However, treatments are limited...
5.
Earley S, Brayden J
Physiol Rev
. 2015 Apr;
95(2):645-90.
PMID: 25834234
The mammalian genome encodes 28 distinct members of the transient receptor potential (TRP) superfamily of cation channels, which exhibit varying degrees of selectivity for different ionic species. Multiple TRP channels...
6.
Dabertrand F, Kroigaard C, Bonev A, Cognat E, Dalsgaard T, Domenga-Denier V, et al.
Proc Natl Acad Sci U S A
. 2015 Feb;
112(7):E796-805.
PMID: 25646445
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), caused by dominant mutations in the NOTCH3 receptor in vascular smooth muscle, is a genetic paradigm of small vessel disease...
7.
Li Y, Baylie R, Tavares M, Brayden J
J Cereb Blood Flow Metab
. 2014 Aug;
34(10):1706-14.
PMID: 25099756
Cerebral parenchymal arterioles (PAs) have a critical role in assuring appropriate blood flow and perfusion pressure within the brain. They are unique in contrast to upstream pial arteries, as defined...
8.
Cipolla M, Chan S, Sweet J, Tavares M, Gokina N, Brayden J
Stroke
. 2014 Jun;
45(8):2425-30.
PMID: 24968928
Background And Purpose: Parenchymal arterioles (PAs) are high-resistance vessels in the brain that connect pial vessels to the microcirculation. We previously showed that PAs have increased vasoconstriction after ischemia and...
9.
Cipolla M, Sweet J, Chan S, Tavares M, Gokina N, Brayden J
J Appl Physiol (1985)
. 2014 May;
117(1):53-9.
PMID: 24790017
Brain parenchymal arterioles (PAs) are high-resistance vessels that branch off pial arteries and perfuse the brain parenchyma. PAs are the target of cerebral small vessel disease and have been shown...
10.
Mercado J, Baylie R, Navedo M, Yuan C, Scott J, Nelson M, et al.
J Gen Physiol
. 2014 Apr;
143(5):559-75.
PMID: 24778429
Transient receptor potential vanilloid 4 (TRPV4) channels are Ca(2+)-permeable, nonselective cation channels expressed in multiple tissues, including smooth muscle. Although TRPV4 channels play a key role in regulating vascular tone,...