Joseph C Mellor
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Explore the profile of Joseph C Mellor including associated specialties, affiliations and a list of published articles.
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17
Citations
1101
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Recent Articles
1.
Luck K, Kim D, Lambourne L, Spirohn K, Begg B, Bian W, et al.
Nature
. 2020 Apr;
580(7803):402-408.
PMID: 32296183
Global insights into cellular organization and genome function require comprehensive understanding of the interactome networks that mediate genotype-phenotype relationships. Here we present a human 'all-by-all' reference interactome map of human...
2.
Highly Combinatorial Genetic Interaction Analysis Reveals a Multi-Drug Transporter Influence Network
Celaj A, Gebbia M, Musa L, Cote A, Snider J, Wong V, et al.
Cell Syst
. 2019 Nov;
10(1):25-38.e10.
PMID: 31668799
Many traits are complex, depending non-additively on variant combinations. Even in model systems, such as the yeast S. cerevisiae, carrying out the high-order variant-combination testing needed to dissect complex traits...
3.
Colabella C, Corte L, Roscini L, Bassetti M, Tascini C, Mellor J, et al.
IMA Fungus
. 2018 Jul;
9(1):91-105.
PMID: 30018874
Species identification of yeasts and other Fungi is currently carried out with Sanger sequences of selected molecular markers, mainly from the ribosomal DNA operon, characterized by hundreds of tandem repeats...
4.
Mellor J, Stone M, Keane J
Trends Hear
. 2018 Jun;
22:2331216518776817.
PMID: 29848183
The ubiquity and cheapness of miniature low-power sensors, digital processing, and large amounts of storage contained in small packages has heralded the ability to acquire large amounts of data about...
5.
Diaz-Mejia J, Celaj A, Mellor J, Cote A, Balint A, Ho B, et al.
Mol Syst Biol
. 2018 May;
14(5):e7985.
PMID: 29807908
Condition-dependent genetic interactions can reveal functional relationships between genes that are not evident under standard culture conditions. State-of-the-art yeast genetic interaction mapping, which relies on robotic manipulation of arrays of...
6.
Weile J, Sun S, Cote A, Knapp J, Verby M, Mellor J, et al.
Mol Syst Biol
. 2017 Dec;
13(12):957.
PMID: 29269382
Although we now routinely sequence human genomes, we can confidently identify only a fraction of the sequence variants that have a functional impact. Here, we developed a deep mutational scanning...
7.
van Leeuwen J, Pons C, Mellor J, Yamaguchi T, Friesen H, Koschwanez J, et al.
Science
. 2016 Nov;
354(6312).
PMID: 27811238
Genetic suppression occurs when the phenotypic defects caused by a mutation in a particular gene are rescued by a mutation in a second gene. To explore the principles of genetic...
8.
Wong L, Sinha S, Bergeron J, Mellor J, Giaever G, Flaherty P, et al.
PLoS Genet
. 2016 Sep;
12(9):e1006275.
PMID: 27588687
The emergence and prevalence of drug resistance demands streamlined strategies to identify drug resistant variants in a fast, systematic and cost-effective way. Methods commonly used to understand and predict drug...
9.
Yachie N, Petsalaki E, Mellor J, Weile J, Jacob Y, Verby M, et al.
Mol Syst Biol
. 2016 Apr;
12(4):863.
PMID: 27107012
High-throughput binary protein interaction mapping is continuing to extend our understanding of cellular function and disease mechanisms. However, we remain one or two orders of magnitude away from a complete...
10.
Das J, Vo T, Wei X, Mellor J, Tong V, Degatano A, et al.
Sci Signal
. 2013 May;
6(276):ra38.
PMID: 23695164
The fission yeast Schizosaccharomyces pombe has more metazoan-like features than the budding yeast Saccharomyces cerevisiae, yet it has similarly facile genetics. We present a large-scale verified binary protein-protein interactome network,...