Joseph C Corbo
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Explore the profile of Joseph C Corbo including associated specialties, affiliations and a list of published articles.
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67
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2348
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Recent Articles
1.
Friedman R, Ramu A, Lichtarge S, Wu Y, Tripp L, Lyon D, et al.
Cell Syst
. 2025 Jan;
16(1):101163.
PMID: 39778579
Deep learning is a promising strategy for modeling cis-regulatory elements. However, models trained on genomic sequences often fail to explain why the same transcription factor can activate or repress transcription...
2.
Volkov L, Ogawa Y, Somjee R, Vedder H, Powell H, Poria D, et al.
Proc Natl Acad Sci U S A
. 2024 Nov;
121(47):e2402121121.
PMID: 39531499
The role of transcription factors in photoreceptor gene regulation is fairly well understood, but knowledge of the cell-type-specific function of transcriptional cofactors remains incomplete. Here, we show that the transcriptional...
3.
Arbore R, Barbosa S, Brejcha J, Ogawa Y, Liu Y, Nicolai M, et al.
Science
. 2024 Oct;
386(6721):eadp7710.
PMID: 39480920
Parrots produce stunning plumage colors through unique pigments called psittacofulvins. However, the mechanism underlying their ability to generate a spectrum of vibrant yellows, reds, and greens remains enigmatic. We uncover...
4.
Kolesnikov A, Murphy D, Corbo J, Kefalov V
Proc Natl Acad Sci U S A
. 2024 Mar;
121(11):e2316118121.
PMID: 38442152
Retinitis pigmentosa (RP) is a common form of retinal dystrophy that can be caused by mutations in any one of dozens of rod photoreceptor genes. The genetic heterogeneity of RP...
5.
Loell K, Friedman R, Myers C, Corbo J, Cohen B, White M
PLoS Comput Biol
. 2024 Jan;
20(1):e1011802.
PMID: 38227575
The effects of transcription factor binding sites (TFBSs) on the activity of a cis-regulatory element (CRE) depend on the local sequence context. In rod photoreceptors, binding sites for the transcription...
6.
Gerhards J, Volkov L, Corbo J, Malan D, Sasse P
Pflugers Arch
. 2023 Nov;
475(12):1409-1419.
PMID: 37987804
Optogenetics is a technology using light-sensitive proteins to control signaling pathways and physiological processes in cells and organs and has been applied in neuroscience, cardiovascular sciences, and many other research...
7.
Friedman R, Ramu A, Lichtarge S, Myers C, Granas D, Gause M, et al.
bioRxiv
. 2023 Sep;
PMID: 37662358
-regulatory elements (CREs) direct gene expression in health and disease, and models that can accurately predict their activities from DNA sequences are crucial for biomedicine. Deep learning represents one emerging...
8.
Zhao S, Hong C, Myers C, Granas D, White M, Corbo J, et al.
Nat Genet
. 2023 Jan;
55(2):346-354.
PMID: 36635387
Massively parallel reporter gene assays are key tools in regulatory genomics but cannot be used to identify cell-type-specific regulatory elements without performing assays serially across different cell types. To address...
9.
Toomey M, Marques C, Araujo P, Huang D, Zhong S, Liu Y, et al.
Curr Biol
. 2022 Sep;
32(19):4201-4214.e12.
PMID: 36049480
Red coloration is a salient feature of the natural world. Many vertebrates produce red color by converting dietary yellow carotenoids into red ketocarotenoids via an unknown mechanism. Here, we show...
10.
Friedman R, Granas D, Myers C, Corbo J, Cohen B, White M
Elife
. 2021 Sep;
10.
PMID: 34486522
Enhancers and silencers often depend on the same transcription factors (TFs) and are conflated in genomic assays of TF binding or chromatin state. To identify sequence features that distinguish enhancers...