Joseph C Cheng
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Explore the profile of Joseph C Cheng including associated specialties, affiliations and a list of published articles.
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12
Citations
376
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Recent Articles
1.
Price S, Beckham T, Cheng J, Lu P, Liu X, Norris J
Int J Stem Cell Res Ther
. 2016 Jun;
2(2).
PMID: 27275017
Mesenchymal stem cells (MSCs) are a multipotent cell population acquired most prominently from bone marrow with the capacity to differentiate into osteoblasts, chondrocytes, adipocytes, and others. MSCs demonstrate the capacity...
2.
Cheng J, Secondary J, Burke W, Fedoroff J, Dwyer R
Curr Psychiatry Rep
. 2015 May;
17(7):55.
PMID: 25980508
The neuroanatomical correlates of human sexual desire, arousal, and behavior have been characterized in recent years with functional brain imaging techniques such as magnetic resonance imaging (MRI) and positron emission...
3.
Beckham T, Cheng J, Lu P, Marrison S, Norris J, Liu X
PLoS One
. 2013 Oct;
8(10):e76593.
PMID: 24098536
The tumor suppressor PTEN is now understood to regulate cellular processes at the cytoplasmic membrane, where it classically regulates PI3K signaling, as well as in the nucleus where multiple roles...
4.
Cheng J, Bai A, Beckham T, Marrison S, Yount C, Young K, et al.
J Clin Invest
. 2013 Oct;
123(10):4344-58.
PMID: 24091326
Escape of prostate cancer (PCa) cells from ionizing radiation-induced (IR-induced) killing leads to disease progression and cancer relapse. The influence of sphingolipids, such as ceramide and its metabolite sphingosine 1-phosphate,...
5.
Beckham T, Cheng J, Marrison S, Norris J, Liu X
Adv Cancer Res
. 2013 Jan;
117:1-36.
PMID: 23290775
Non-surgical therapies for human malignancies must negotiate complex cell signaling pathways to impede cancer cell growth, ideally promoting death of cancer cells while sparing healthy tissue. For most of the...
6.
Beckham T, Lu P, Jones E, Marrison T, Lewis C, Cheng J, et al.
J Pharmacol Exp Ther
. 2012 Oct;
344(1):167-78.
PMID: 23086228
Treatment of pancreatic cancer that cannot be surgically resected currently relies on minimally beneficial cytotoxic chemotherapy with gemcitabine. As the fourth leading cause of cancer-related death in the United States...
7.
Beckham T, Lu P, Cheng J, Zhao D, Turner L, Zhang X, et al.
Int J Cancer
. 2012 Feb;
131(9):2034-43.
PMID: 22322590
Invasiveness is one of the key features of aggressive prostate cancer; however, our understanding of the precise mechanisms effecting invasion remains limited. The ceramide hydrolyzing enzyme acid ceramidase (AC), overexpressed...
8.
Beckham T, Elojeimy S, Cheng J, Turner L, Hoffman S, Norris J, et al.
Expert Opin Ther Targets
. 2010 Mar;
14(5):529-39.
PMID: 20334489
Importance Of The Field: Ceramide accumulation has been shown to be a conserved mechanism of apoptosis initiation in normal physiological processes as well as in response to cancer treatments. Therefore,...
9.
Liu X, Cheng J, Turner L, Elojeimy S, Beckham T, Bielawska A, et al.
Expert Opin Ther Targets
. 2009 Oct;
13(12):1449-58.
PMID: 19874262
Bioactive sphingolipids, such as ceramide, sphingosine and sphingosine-1-phosphate are known bio-effector molecules which play important roles in various aspects of cancer biology including cell proliferation, growth arrest, apoptosis, metastasis, senescence...
10.
Mahdy A, Cheng J, Li J, Elojeimy S, Meacham W, Turner L, et al.
Mol Ther
. 2008 Dec;
17(3):430-8.
PMID: 19107118
Radiation resistance in a subset of prostate tumors remains a challenge to prostate cancer radiotherapy. The current study on the effects of radiation on prostate cancer cells reveals that radiation...