Joseph Belanoff
Overview
Explore the profile of Joseph Belanoff including associated specialties, affiliations and a list of published articles.
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Articles
12
Citations
217
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Recent Articles
1.
Meyer M, Meijer O, Hunt H, Belanoff J, Lima A, de Kloet E, et al.
Mol Neurobiol
. 2023 Aug;
61(1):1-14.
PMID: 37566177
Glucocorticoids exert antiinflammatory, antiproliferative and immunosupressive effects. Paradoxically they may also enhance inflammation particularly in the nervous system, as shown in Cushing´ syndrome and neurodegenerative disorders of humans and models...
2.
De Nicola A, Meyer M, Guennoun R, Schumacher M, Hunt H, Belanoff J, et al.
Int J Mol Sci
. 2020 Apr;
21(6).
PMID: 32244957
Glucocorticoids are crucial for stress-coping, resilience, and adaptation. However, if the stress hormones become dysregulated, the vulnerability to stress-related diseases is enhanced. In this brief review, we discuss the role...
3.
Meyer M, Kruse M, Garay L, Lima A, Roig P, Hunt H, et al.
Brain Res
. 2019 Nov;
1727:146551.
PMID: 31726042
The Wobbler mouse spinal cord shows vacuolated motoneurons, glial reaction, inflammation and abnormal glutamatergic parameters. Wobblers also show deficits of motor performance. These conditions resemble amyotrophic lateral sclerosis (ALS). Wobbler...
4.
Meyer M, Lara A, Hunt H, Belanoff J, de Kloet E, Deniselle M, et al.
Neuroscience
. 2018 Jun;
384:384-396.
PMID: 29890290
Wobbler mice are experimental models for amyotrophic lateral sclerosis. As such they show motoneuron degeneration, motor deficits, and astrogliosis and microgliosis of the spinal cord. Additionally, Wobbler mice show increased...
5.
Block T, Kushner H, Kalin N, Nelson C, Belanoff J, Schatzberg A
Biol Psychiatry
. 2018 Mar;
84(1):46-54.
PMID: 29523415
Background: Patients with psychotic depression exhibit elevated cortisol levels. Competitively antagonizing cortisol at the glucocorticoid receptor with mifepristone demonstrated therapeutic benefit in early studies of patients with psychotic depression. We...
6.
Hunt H, Donaldson K, Strem M, Zann V, Leung P, Sweet S, et al.
Clin Pharmacol Drug Dev
. 2017 Oct;
7(4):408-421.
PMID: 28967708
CORT125134 is an orally active, high-affinity, selective antagonist of the glucocorticoid receptor that is being developed for indications that may benefit from the modulation of cortisol activity. This first-in-human study...
7.
Block T, Petrides G, Kushner H, Kalin N, Belanoff J, Schatzberg A
J Clin Psychopharmacol
. 2017 Jul;
37(5):505-511.
PMID: 28708736
Background: Psychotic depression has no Food and Drug Administration-approved treatment. Patients demonstrate significant dysregulation of the hypothalamic-pituitary-adrenal axis providing a biologically targeted treatment opportunity. The purpose of this study was...
8.
Andrade C, Shaikh S, Narayan L, Blasey C, Belanoff J
J Neural Transm (Vienna)
. 2011 Sep;
119(3):337-44.
PMID: 21922193
Mifepristone, a glucocorticoid and progesterone receptor antagonist, has been shown to attenuate retrograde amnesia induced by repeated electroconvulsive shocks (ECS). We examined the efficacy of CORT 108297, a selective glucocorticoid...
9.
Clark R, Ray N, Williams K, Blaney P, Ward S, Crackett P, et al.
Bioorg Med Chem Lett
. 2008 Jan;
18(4):1312-7.
PMID: 18226897
Addition of the 4-fluorophenylpyrazole group to the previously described 2-azadecalin glucocorticoid receptor (GR) antagonist 1 resulted in significantly enhanced functional activity. SAR of the bridgehead substituent indicated that whereas groups...
10.
DeBattista C, Belanoff J, Glass S, Khan A, Horne R, Blasey C, et al.
Biol Psychiatry
. 2006 Aug;
60(12):1343-9.
PMID: 16889757
Background: Abnormalities in the hypothalamic pituitary adrenal axis have been implicated in the pathophysiology of psychotic major depression (PMD). Recent studies have suggested that the antiglucocorticoid, mifepristone might have a...