Joseph A Mangan
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Explore the profile of Joseph A Mangan including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
966
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Recent Articles
1.
Hinds J, Laing K, Mangan J, Butcher P
Comp Funct Genomics
. 2008 Jul;
3(4):333-7.
PMID: 18629281
No abstract available.
2.
Stewart G, Wernisch L, Stabler R, Mangan J, Hinds J, Laing K, et al.
Comp Funct Genomics
. 2008 Jul;
3(4):348-51.
PMID: 18629273
The regulation of heat shock protein (HSP) expression is critically important to pathogens such as Mycobacterium tuberculosis and dysregulation of the heat shock response results in increased immune recognition of...
3.
Bacon J, James B, Wernisch L, Williams A, Morley K, Hatch G, et al.
Tuberculosis (Edinb)
. 2004 Jun;
84(3-4):205-17.
PMID: 15207490
We investigated how Mycobacterium tuberculosis responded to a reduced oxygen tension in terms of its pathogenicity and gene expression by growing cells under either aerobic or low-oxygen conditions in chemostat...
4.
Li M, Waddell S, Monahan I, Mangan J, Martin S, Everett M, et al.
FEMS Microbiol Lett
. 2004 Apr;
233(2):333-9.
PMID: 15063504
Alternative sigma factors are key global regulators that coordinate bacterial responses to environmental changes necessary for adaptation and survival. In turn these sigma factors are controlled by regulators such as...
5.
Schnappinger D, Ehrt S, Voskuil M, Liu Y, Mangan J, Monahan I, et al.
J Exp Med
. 2003 Sep;
198(5):693-704.
PMID: 12953091
Little is known about the biochemical environment in phagosomes harboring an infectious agent. To assess the state of this organelle we captured the transcriptional responses of Mycobacterium tuberculosis (MTB) in...
6.
Stabler R, Hinds J, Witney A, Isherwood K, Oyston P, Titball R, et al.
Adv Exp Med Biol
. 2003 May;
529:47-9.
PMID: 12756727
No abstract available.
7.
Stewart G, Wernisch L, Stabler R, Mangan J, Hinds J, Laing K, et al.
Microbiology (Reading)
. 2002 Oct;
148(Pt 10):3129-3138.
PMID: 12368446
Regulation of the expression of heat-shock proteins plays an important role in the pathogenesis of Mycobacterium tuberculosis. The heat-shock response of bacteria involves genome-wide changes in gene expression. A combination...
8.
Li M, Monahan I, Waddell S, Mangan J, Martin S, Everett M, et al.
Microbiology (Reading)
. 2001 Aug;
147(Pt 8):2293-2305.
PMID: 11496006
Identifying genes that are differentially expressed by Mycobacterium bovis BCG after phagocytosis by macrophages will facilitate the understanding of the molecular mechanisms of host cell-intracellular pathogen interactions. To identify such...
9.
Wren B, Stabler R, Das S, Butcher P, Mangan J, Clarke J, et al.
Microbiology (Reading)
. 1998 Jun;
144 ( Pt 5):1205-1211.
PMID: 9611795
Scrutiny of sequence data from the Mycobacterium leprae genome sequencing project identified the presence of a gene encoding a 268-amino-acid polypeptide which is highly similar to a pore-forming haemolysin/cytotoxin virulence...