Jose W Saldanha
Overview
Explore the profile of Jose W Saldanha including associated specialties, affiliations and a list of published articles.
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26
Citations
478
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Recent Articles
1.
Lisgarten D, Palmer R, Lobley C, Naylor C, Chowdhry B, Al-Kurdi Z, et al.
Chem Cent J
. 2017 Nov;
11(1):73.
PMID: 29086855
The crystal structure of a commercially available form of human recombinant (HR) insulin, Insugen (I), used in the treatment of diabetes has been determined to 0.92 Å resolution using low...
2.
Smith L, Bochkareva A, Rolfe M, Hunt D, Kahramanoglou C, Braun Y, et al.
Nucleic Acids Res
. 2017 May;
45(11):6600-6612.
PMID: 28482027
Mycobacterium tuberculosis (MTb) is the causative agent of pulmonary tuberculosis (TB). MTb colonizes the human lung, often entering a non-replicating state before progressing to life-threatening active infections. Transcriptional reprogramming is...
3.
Wedatilake Y, Niazi R, Fassone E, Powell C, Pearce S, Plagnol V, et al.
Orphanet J Rare Dis
. 2016 Jul;
11(1):90.
PMID: 27370603
Background: TRNT1 (CCA-adding transfer RNA nucleotidyl transferase) enzyme deficiency is a new metabolic disease caused by defective post-transcriptional modification of mitochondrial and cytosolic transfer RNAs (tRNAs). Results: We investigated four...
4.
Smith S, Towers N, Saldanha J, Shang C, Mahmood S, Taylor W, et al.
Dev Biol
. 2016 May;
416(2):373-88.
PMID: 27217161
Adprhl1, a member of the ADP-ribosylhydrolase protein family, is expressed exclusively in the developing heart of all vertebrates. In the amphibian Xenopus laevis, distribution of its mRNA is biased towards...
5.
McCabe M, Hu Y, Gregory L, Gaston-Massuet C, Alatzoglou K, Saldanha J, et al.
Mol Cell Endocrinol
. 2015 Sep;
417:63-72.
PMID: 26375424
KAL1 is implicated in 5% of Kallmann syndrome cases, a disorder which genotypically overlaps with septo-optic dysplasia (SOD). To date, a reporter-based assay to assess the functional consequences of KAL1...
6.
Kanabus M, Shahni R, Saldanha J, Murphy E, Plagnol V, Vant Hoff W, et al.
J Inherit Metab Dis
. 2015 Jan;
38(2):211-9.
PMID: 25595726
Whole exome sequencing was used to investigate the genetic cause of mitochondrial disease in two siblings with a syndrome of congenital lamellar cataracts associated with nephrocalcinosis, medullary cysts and 3-methylglutaconic...
7.
Nikoloudis D, Pitts J, Saldanha J
PeerJ
. 2014 Jul;
2:e456.
PMID: 25071986
Classification of antibody complementarity-determining region (CDR) conformations is an important step that drives antibody modelling and engineering, prediction from sequence, directed mutagenesis and induced-fit studies, and allows inferences on sequence-to-structure...
8.
Nikoloudis D, Pitts J, Saldanha J
PeerJ
. 2014 Jul;
2:e455.
PMID: 25071985
The accurate prediction of the conformation of Complementarity-Determining Regions (CDRs) is important in modelling antibodies for protein engineering applications. Specifically, the Canonical paradigm has proved successful in predicting the CDR...
9.
Feinberg H, Saldanha J, Diep L, Goel A, Widom A, Veldman G, et al.
Alzheimers Res Ther
. 2014 Jul;
6(3):31.
PMID: 25024748
Introduction: Immunotherapy targeting amyloid-β peptide is under active clinical investigation for treatment of Alzheimer's disease (AD). Among the hypotheses being investigated for impact on clinical outcome are the preferred epitope...
10.
Pennell S, Declais A, Li J, Haire L, Berg W, Saldanha J, et al.
Cell Rep
. 2014 Jul;
8(1):84-93.
PMID: 24981866
FAN1 is a structure-selective DNA repair nuclease with 5' flap endonuclease activity, involved in the repair of interstrand DNA crosslinks. It is the only eukaryotic protein with a virus-type replication-repair...