Jose L Mendez-Andino
Overview
Explore the profile of Jose L Mendez-Andino including associated specialties, affiliations and a list of published articles.
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Articles
6
Citations
25
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Recent Articles
1.
Mendez-Andino J, Wos J
Drug Discov Today
. 2007 Nov;
12(21-22):972-9.
PMID: 17993417
Despite the high number of drug-discovery programs dedicated to finding small-molecule MCH-R1 antagonists for the treatment of obesity and/or mood disorders, a very limited number of these have progressed into...
2.
Mendez-Andino J, Colson A, Meyers K, Mitchell M, Hodge K, Howard J, et al.
Bioorg Med Chem
. 2007 Jan;
15(5):2092-105.
PMID: 17236777
The design, synthesis, and biological studies of a novel class of MCH-R1 antagonists based on an aminotetrahydronaphthalene ketopiperazine scaffold is described. Compounds within this class promoted significant body weight reduction...
3.
Meyers K, Mendez-Andino J, Colson A, Warshakoon N, Wos J, Mitchell M, et al.
Bioorg Med Chem Lett
. 2006 Nov;
17(3):819-22.
PMID: 17107796
A direct correlation between hERG binding and QTc prolongation was established for a series of aminomethyl tetrahydronaphthalene ketopiperazine MCH-R1 antagonists. Compounds within this class with greater selectivity over hERG were...
4.
Meyers K, Kim N, Mendez-Andino J, Eric Hu X, Mumin R, Klopfenstein S, et al.
Bioorg Med Chem Lett
. 2006 Nov;
17(3):814-8.
PMID: 17107791
Aminomethyl tetrahydronaphthalene biphenyl carboxamide MCH-R1 antagonists with greater selectivity over hERG were identified. SAR studies addressing two distinct alternatives for structural modifications leading to improve hERG selectivity are described.
5.
Kim N, Meyers K, Mendez-Andino J, Warshakoon N, Ji W, Wos J, et al.
Bioorg Med Chem Lett
. 2006 Aug;
16(20):5445-50.
PMID: 16879961
A substituted 4-aminopiperidine was identified as showing activity in an MCH assay from an HTS effort. Subsequent structural modification of the scaffold led to the identification of a number of...
6.
Warshakoon N, Sheville J, Bhatt R, Ji W, Mendez-Andino J, Meyers K, et al.
Bioorg Med Chem Lett
. 2006 Jul;
16(19):5207-11.
PMID: 16870427
A novel series of substituted quinoline analogs were designed and synthesized as potent and selective melanin concentrating hormone (MCH) antagonists. These analogs show potent (nM) activity (12a-k) with a moderate...