Jose K van den Heuvel
Overview
Explore the profile of Jose K van den Heuvel including associated specialties, affiliations and a list of published articles.
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Articles
15
Citations
490
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Recent Articles
1.
Kroon J, Schilperoort M, In Het Panhuis W, van den Berg R, van Doeselaar L, Verzijl C, et al.
Mol Metab
. 2021 Feb;
47:101179.
PMID: 33548499
Objective: Brown adipose tissue (BAT) displays a strong circadian rhythm in metabolic activity, but it is unclear how this rhythm is regulated. As circulating levels of corticosterone coincide with the...
2.
Koorneef L, van den Heuvel J, Kroon J, Boon M, t Hoen P, Hettne K, et al.
Endocrinology
. 2018 Oct;
159(12):3925-3936.
PMID: 30321321
Medication for nonalcoholic fatty liver disease (NAFLD) is an unmet need. Glucocorticoid (GC) stress hormones drive fat metabolism in the liver, but both full blockade and full stimulation of GC...
3.
Eggink H, Tambyrajah L, van den Berg R, Mol I, van den Heuvel J, Koehorst M, et al.
J Endocrinol
. 2017 Dec;
236(2):85-97.
PMID: 29233934
Bile acids can function in the postprandial state as circulating signaling molecules in the regulation of glucose and lipid metabolism via the transmembrane receptor TGR5 and nuclear receptor FXR. Both...
4.
Li Z, Yi C, Katiraei S, Kooijman S, Zhou E, Chung C, et al.
Gut
. 2017 Nov;
67(7):1269-1279.
PMID: 29101261
Objective: Butyrate exerts metabolic benefits in mice and humans, the underlying mechanisms being still unclear. We aimed to investigate the effect of butyrate on appetite and energy expenditure, and to...
5.
Kroon J, Koorneef L, van den Heuvel J, Verzijl C, van de Velde N, Mol I, et al.
Endocrinology
. 2017 Sep;
159(1):535-546.
PMID: 28938459
Glucocorticoids influence a wide range of metabolic processes in the human body, and excessive glucocorticoid exposure is known to contribute to the development of metabolic disease. We evaluated the utility...
6.
Gumbs M, van den Heuvel J, la Fleur S
Physiol Behav
. 2016 May;
162:161-73.
PMID: 27132202
Obesity is a major health problem characterized by accumulated fat mass. The availability of an energy-dense, highly palatable diet plays an important role in obesity development. Neuropeptide Y (NPY), an...
7.
van den Heuvel J, Boon M, van Hengel I, Peschier-van der Put E, van Beek L, van Harmelen V, et al.
Br J Pharmacol
. 2016 Mar;
173(11):1793-804.
PMID: 26990179
Background And Purpose: High-fat diet consumption results in obesity and chronic low-grade inflammation in adipose tissue. Whereas glucocorticoid receptor (GR) antagonism reduces diet-induced obesity, GR agonism reduces inflammation, the combination...
8.
Mahfouz A, Lelieveldt B, Grefhorst A, van Weert L, Mol I, Sips H, et al.
Proc Natl Acad Sci U S A
. 2016 Jan;
113(10):2738-43.
PMID: 26811448
Steroid receptors are pleiotropic transcription factors that coordinate adaptation to different physiological states. An important target organ is the brain, but even though their effects are well studied in specific...
9.
van den Heuvel J, Eggels L, Van Rozen A, Fliers E, Kalsbeek A, Adan R, et al.
Front Behav Neurosci
. 2016 Jan;
9:358.
PMID: 26733840
Introduction: Conflicting data exist on sensitivity changes of the melanocortin system during diet-induced obesity. We hypothesized that melanocortin sensitivity depends on diet composition, in particular on the fat content rather...
10.
Kooijman S, van den Heuvel J, Rensen P
Trends Endocrinol Metab
. 2015 Oct;
26(11):657-668.
PMID: 26482876
Brown adipose tissue (BAT) activation reduces body fat and metabolic disorders by the enhanced combustion of lipids and glucose into heat. The thermogenic activity of brown adipocytes is primarily driven...