Jose F Moruno-Manchon
Overview
Explore the profile of Jose F Moruno-Manchon including associated specialties, affiliations and a list of published articles.
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12
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1343
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Recent Articles
1.
Peesh P, Blasco-Conesa M, El Hamamy A, Khan R, Guzman G, Honarpisheh P, et al.
Nat Commun
. 2025 Feb;
16(1):1767.
PMID: 39971928
Recent studies have highlighted the crucial role of microglia (MG) and their interactions with the gut microbiome in post-stroke neuroinflammation. The activation of immunoregulatory pathways, including the aryl hydrocarbon receptor...
2.
Escarcega R, Patil A, Moruno-Manchon J, Urayama A, Marrelli S, Kim N, et al.
J Biol Chem
. 2023 Aug;
299(10):105157.
PMID: 37579947
Noncanonical base pairing between four guanines (G) within single-stranded G-rich sequences leads to formation of а G-quartet. Self-stacking of G-quartets results in a columnar four-stranded DNA structure known as the...
3.
Escarcega R, Patil A, Meyer M, Moruno-Manchon J, Silvagnoli A, McCullough L, et al.
Mol Cell Neurosci
. 2023 Mar;
125:103826.
PMID: 36858083
Tardigrades are microscopic invertebrates, which are capable of withstanding extreme environmental conditions, including high levels of radiation. A Tardigrade protein, Dsup (Damage Suppressor), protects the Tardigrade's DNA during harsh environmental...
4.
Noh B, McCullough L, Moruno-Manchon J
Neural Regen Res
. 2022 Jul;
18(1):31-37.
PMID: 35799505
Stroke is the second leading cause of death and a major cause of disability worldwide, and biological sex is an important determining factor in stroke incidence and pathology. From childhood...
5.
Patrizz A, Moruno-Manchon J, OKeefe L, Doran S, Patel A, Venna V, et al.
Cells
. 2021 Aug;
10(7).
PMID: 34359998
Ischemic stroke triggers a series of complex pathophysiological processes including autophagy. Differential activation of autophagy occurs in neurons derived from males versus females after stressors such as nutrient deprivation. Whether...
6.
Tabor N, Ngwa C, Mitteaux J, Meyer M, Moruno-Manchon J, Zhu L, et al.
Aging (Albany NY)
. 2021 Jun;
13(12):15917-15941.
PMID: 34139671
The G-quadruplex (G4-DNA or G4) is a secondary DNA structure formed by DNA sequences containing multiple runs of guanines. While it is now firmly established that stabilized G4s lead to...
7.
Klionsky D, Abdel-Aziz A, Abdelfatah S, Abdellatif M, Abdoli A, Abel S, et al.
Autophagy
. 2021 Feb;
17(1):1-382.
PMID: 33634751
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our...
8.
Lejault P, Moruno-Manchon J, Vemu S, Honarpisheh P, Zhu L, Kim N, et al.
Autophagy
. 2020 May;
16(12):2252-2259.
PMID: 32420812
Guanine-rich DNA strands can form secondary structures known as G-quadruplexes (G4-DNA or G4s). G4-DNA is important for the regulation of replication and transcription. We recently showed that the expression of...
9.
Moruno-Manchon J, Lejault P, Wang Y, McCauley B, Honarpisheh P, Morales Scheihing D, et al.
Elife
. 2020 Feb;
9.
PMID: 32043463
Guanine-rich DNA sequences can fold into four-stranded G-quadruplex (G4-DNA) structures. G4-DNA regulates replication and transcription, at least in cancer cells. Here, we demonstrate that, in neurons, pharmacologically stabilizing G4-DNA with...
10.
Moruno-Manchon J, Uzor N, Ambati C, Shetty V, Putluri N, Jagannath C, et al.
Cell Death Dis
. 2018 May;
9(5):521.
PMID: 29743513
Autophagy is a degradative pathway for removing aggregated proteins, damaged organelles, and parasites. Evidence indicates that autophagic pathways differ between cell types. In neurons, autophagy plays a homeostatic role, compared...