Jose Carlos Valle-Casuso
Overview
Explore the profile of Jose Carlos Valle-Casuso including associated specialties, affiliations and a list of published articles.
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18
Citations
902
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Recent Articles
11.
White T, Brandariz-Nunez A, Valle-Casuso J, Amie S, Nguyen L, Kim B, et al.
Cell Host Microbe
. 2013 Apr;
13(4):441-51.
PMID: 23601106
SAMHD1 is a cellular enzyme that depletes intracellular deoxynucleoside triphosphates (dNTPs) and inhibits the ability of retroviruses, notably HIV-1, to infect myeloid cells. Although SAMHD1 is expressed in both cycling...
12.
Di Nunzio F, Fricke T, Miccio A, Valle-Casuso J, Perez P, Souque P, et al.
Virology
. 2013 Mar;
440(1):8-18.
PMID: 23523133
The early steps of HIV-1 replication involve the entry of HIV-1 into the nucleus, which is characterized by viral interactions with nuclear pore components. HIV-1 developed an evolutionary strategy to...
13.
White T, Brandariz-Nunez A, Valle-Casuso J, Amie S, Nguyen L, Kim B, et al.
Virology
. 2012 Nov;
436(1):81-90.
PMID: 23158101
The human SAMHD1 protein is a novel retroviral restriction factor expressed in myeloid cells. Previous work has correlated the deoxynucleotide triphosphohydrolase activity of SAMHD1 with its ability to block HIV-1...
14.
Brandariz-Nunez A, Roa A, Valle-Casuso J, Biris N, Ivanov D, Diaz-Griffero F
Virology
. 2012 Oct;
435(2):463-71.
PMID: 23084420
Recent findings suggested that the SUMO-interacting motifs (SIMs) present in the human TRIM5α (TRIM5α(hu)) protein play an important role in the ability of TRIM5α(hu) to restrict N-MLV. Here we explored...
15.
Gangoso E, Ezan P, Valle-Casuso J, Herrero-Gonzalez S, Koulakoff A, Medina J, et al.
Glia
. 2012 Sep;
60(12):2040-9.
PMID: 22987484
In diverse brain pathologies, astrocytes become reactive and undergo profound phenotypic changes. Connexin43 (Cx43), the main gap junction channel-forming protein in astrocytes, is one of the proteins modified in reactive...
16.
Brandariz-Nunez A, Valle-Casuso J, White T, Laguette N, Benkirane M, Brojatsch J, et al.
Retrovirology
. 2012 Jun;
9:49.
PMID: 22691373
Background: SAMHD1 is a nuclear protein that blocks lentiviral infection before reverse transcription in macrophages and dendritic cells. The viral accessory protein Vpx overcomes the SAMHD1-mediated lentiviral block by inducing...
17.
Valle-Casuso J, Di Nunzio F, Yang Y, Reszka N, Lienlaf M, Arhel N, et al.
J Virol
. 2012 Mar;
86(10):5931-6.
PMID: 22398280
TNPO3 is a nuclear importer required for HIV-1 infection. Here, we show that depletion of TNPO3 leads to an HIV-1 block after nuclear import but prior to integration. To investigate...
18.
Valle-Casuso J, Gonzalez-Sanchez A, Medina J, Tabernero A
PLoS One
. 2012 Mar;
7(2):e32448.
PMID: 22384254
In previous work we showed that endothelin-1 (ET-1) increases the rate of glucose uptake in astrocytes, an important aspect of brain function since glucose taken up by astrocytes is used...
19.
Herrero-Gonzalez S, Valle-Casuso J, Sanchez-Alvarez R, Giaume C, Medina J, Tabernero A
Glia
. 2008 Aug;
57(2):222-33.
PMID: 18756537
In previous studies, we showed that endothelin-1 increased astrocyte proliferation and glucose uptake. These effects were similar to those observed with other gap junction inhibitors, such as carbenoxolone (CBX). Because...