Jose A De Santiago-Castillo
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Explore the profile of Jose A De Santiago-Castillo including associated specialties, affiliations and a list of published articles.
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10
Citations
241
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Recent Articles
1.
De Jesus-Perez J, Castro-Chong A, Shieh R, Hernandez-Carballo C, De Santiago-Castillo J, Arreola J
J Gen Physiol
. 2015 Dec;
147(1):25-37.
PMID: 26666914
CLC-2 channels are dimeric double-barreled chloride channels that open in response to hyperpolarization. Hyperpolarization activates protopore gates that independently regulate the permeability of the pore in each subunit and the...
2.
Sanchez-Rodriguez J, De Santiago-Castillo J, Contreras-Vite J, Nieto-Delgado P, Castro-Chong A, Arreola J
J Physiol
. 2012 Jul;
590(17):4239-53.
PMID: 22753549
The interaction of either H(+) or Cl(-) ions with the fast gate is the major source of voltage (V(m)) dependence in ClC Cl(-) channels. However, the mechanism by which these...
3.
De Santiago-Castillo J, Covarrubias M, Sanchez-Rodriguez J, Perez-Cornejo P, Arreola J
Channels (Austin)
. 2010 Oct;
4(5):422-8.
PMID: 20935453
In silico simulation based on Markov chains is a powerful way to describe and predict the activity of many transport proteins including ion channels. However, modeling and simulation using realistic...
4.
Sanchez-Rodriguez J, De Santiago-Castillo J, Arreola J
J Physiol
. 2010 May;
588(Pt 14):2545-56.
PMID: 20498235
It has been shown that the voltage (V(m)) dependence of ClC Cl(-) channels is conferred by interaction of the protopore gate with H(+) ions. However, in this paper we present...
5.
Hernandez-Carballo C, De Santiago-Castillo J, Rosales-Saavedra T, Perez-Cornejo P, Arreola J
Pflugers Arch
. 2010 May;
460(3):633-44.
PMID: 20454973
The volume-sensitive chloride current (I(ClVol)) exhibit a time-dependent decay presumably due to channel inactivation. In this work, we studied the effects of chloride ions (Cl(-)) and H(+) ions on I(ClVol)...
6.
Kaulin Y, De Santiago-Castillo J, Rocha C, Nadal M, Rudy B, Covarrubias M
J Neurosci
. 2009 Mar;
29(10):3242-51.
PMID: 19279261
The neuronal subthreshold-operating A-type K(+) current regulates electrical excitability, spike timing, and synaptic integration and plasticity. The Kv4 channels underlying this current have been implicated in epilepsy, regulation of dopamine...
7.
Arreola J, De Santiago-Castillo J, Sanchez J, Nieto P
J Physiol
. 2008 Nov;
586(22):5289.
PMID: 19011132
No abstract available.
8.
Covarrubias M, Bhattacharji A, De Santiago-Castillo J, Dougherty K, Kaulin Y, Na-Phuket T, et al.
Neurochem Res
. 2008 Mar;
33(8):1558-67.
PMID: 18357523
Kv4 channel complexes mediate the neuronal somatodendritic A-type K(+) current (I(SA)), which plays pivotal roles in dendritic signal integration. These complexes are composed of pore-forming voltage-gated alpha-subunits (Shal/Kv4) and at...
9.
Dougherty K, De Santiago-Castillo J, Covarrubias M
J Gen Physiol
. 2008 Feb;
131(3):257-73.
PMID: 18299396
Kv4 channels mediate the somatodendritic A-type K+ current (I(SA)) in neurons. The availability of functional Kv4 channels is dynamically regulated by the membrane potential such that subthreshold depolarizations render Kv4...
10.
Amarillo Y, De Santiago-Castillo J, Dougherty K, Maffie J, Kwon E, Covarrubias M, et al.
J Physiol
. 2008 Feb;
586(8):2093-106.
PMID: 18276729
Kv4 channels mediate most of the somatodendritic subthreshold operating A-type current (I(SA)) in neurons. This current plays essential roles in the regulation of spike timing, repetitive firing, dendritic integration and...