Jose-Andres C Portillo
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Explore the profile of Jose-Andres C Portillo including associated specialties, affiliations and a list of published articles.
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27
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648
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Recent Articles
1.
Vos S, Portillo J, Hubal A, Bapputty R, Pfaff A, Aaron R, et al.
Diabetes
. 2025 Feb;
PMID: 39976665
The unfolded protein response (UPR) drives events that promote diabetic retinopathy including VEGF upregulation in Müller cells. How UPR is activated in vivo in the diabetic retina is not well...
2.
Portillo J, Pfaff A, Vos S, Weng M, Nagaraj R, Subauste C
Cells
. 2024 Mar;
13(5.
PMID: 38474393
CD40 induces pro-inflammatory responses in endothelial and Müller cells and is required for the development of diabetic retinopathy (DR). CD40 is upregulated in these cells in patients with DR. CD40...
3.
Portillo J, Yu J, Vos S, Bapputty R, Lopez Corcino Y, Hubal A, et al.
Diabetologia
. 2022 Aug;
65(12):2157-2171.
PMID: 35920844
Aims/hypothesis: CD40 expressed in Müller cells is a central driver of diabetic retinopathy. CD40 causes phospholipase Cγ1 (PLCγ1)-dependent ATP release in Müller cells followed by purinergic receptor (P2X)-dependent production of...
4.
Yu J, Daw J, Portillo J, Subauste C
Invest Ophthalmol Vis Sci
. 2021 Sep;
62(12):22.
PMID: 34546322
Purpose: CD40 is an upstream inducer of inflammation in the diabetic retina. CD40 is upregulated in retinal endothelial cells in diabetes. The purpose of this study was to determine whether...
5.
Portillo J, Yu J, Hansen S, Kern T, Subauste M, Subauste C
FASEB J
. 2021 Mar;
35(3):e21412.
PMID: 33675257
While the administration of anti-CD154 mAbs in mice validated the CD40-CD154 pathway as a target against inflammatory disorders, this approach caused thromboembolism in humans (unrelated to CD40 inhibition) and is...
6.
Lopez Corcino Y, Gonzalez Ferrer S, Mantilla L, Trikeriotis S, Yu J, Kim S, et al.
Cell Microbiol
. 2019 Jul;
21(10):e13084.
PMID: 31290228
Toxoplasma gondii causes retinitis and encephalitis. Avoiding targeting by autophagosomes is key for its survival because T. gondii cannot withstand lysosomal degradation. During invasion of host cells, T. gondii triggers...
7.
Portillo J, Van Grol J, Saffo S, Lopez Corcino Y, Rodriguez M, Fox B, et al.
Infect Immun
. 2019 May;
87(8).
PMID: 31109947
Little is known about whether pathogen invasion of neural tissue is affected by immune-based mechanisms in endothelial cells. We examined the effects of endothelial cell CD40 on invasion of the...
8.
Lopez Corcino Y, Portillo J, Subauste C
Sci Rep
. 2019 Jan;
9(1):669.
PMID: 30679495
Little is known about strategies used by pathogens to facilitate CNS invasion. Toxoplasma gondii reaches the CNS by circulating in blood within leukocytes or as extracellular tachyzoites. T. gondii induces...
9.
Portillo J, Muniz-Feliciano L, Lopez Corcino Y, Lee S, Van Grol J, Parsons S, et al.
PLoS Pathog
. 2017 Oct;
13(10):e1006671.
PMID: 29036202
Targeting of Toxoplasma gondii by autophagy is an effective mechanism by which host cells kill the protozoan. Thus, the parasite must avoid autophagic targeting to survive. Here we show that...
10.
Samuels I, Portillo J, Miao Y, Kern T, Subauste C
Vis Neurosci
. 2017 Oct;
34:E009.
PMID: 28965505
Chronic low grade inflammation is considered to contribute to the development of experimental diabetic retinopathy (DR). We recently demonstrated that lack of CD40 in mice ameliorates the upregulation of inflammatory...