Carlos S Subauste
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Explore the profile of Carlos S Subauste including associated specialties, affiliations and a list of published articles.
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54
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8269
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Recent Articles
1.
Vos S, Portillo J, Hubal A, Bapputty R, Pfaff A, Aaron R, et al.
Diabetes
. 2025 Feb;
PMID: 39976665
The unfolded protein response (UPR) drives events that promote diabetic retinopathy including VEGF upregulation in Müller cells. How UPR is activated in vivo in the diabetic retina is not well...
2.
Hubal A, Vendhoti A, Shaffer C, Vos S, Lopez Corcino Y, Subauste C
PLoS Pathog
. 2025 Jan;
21(1):e1012907.
PMID: 39869638
The intracellular protozoan Toxoplasma gondii manipulates host cell signaling to avoid targeting by autophagosomes and lysosomal degradation. Epidermal Growth Factor Receptor (EGFR) is a mediator of this survival strategy. However,...
3.
Hubal A, Pfaff A, Vos S, Upadhyay M, Bonilha V, Subauste C
J Vis Exp
. 2024 Jun;
(207).
PMID: 38856212
Retinal pigment epithelial cells (RPE) are critical for the proper function of the retina. RPE dysfunction is involved in the pathogenesis of important retinal diseases, such as age-related macular degeneration,...
4.
Portillo J, Pfaff A, Vos S, Weng M, Nagaraj R, Subauste C
Cells
. 2024 Mar;
13(5.
PMID: 38474393
CD40 induces pro-inflammatory responses in endothelial and Müller cells and is required for the development of diabetic retinopathy (DR). CD40 is upregulated in these cells in patients with DR. CD40...
5.
Subauste C, Hubal A
Curr Protoc
. 2023 Sep;
3(9):e871.
PMID: 37695167
Toxoplasma gondii is an obligate intracellular protozoan parasite that commonly infects mammals and birds throughout the world. This protocol describes murine models of acute T. gondii infection, toxoplasmic encephalitis and...
6.
Vos S, Aaron R, Weng M, Daw J, Rodriguez-Rivera E, Subauste C
Invest Ophthalmol Vis Sci
. 2023 Jun;
64(7):17.
PMID: 37294707
Purpose: CD40 is upregulated in the retinas of diabetic mice, drives pro-inflammatory molecule expression, and promotes diabetic retinopathy. The role of CD40 in diabetic retinopathy in humans is unknown. Upregulation...
7.
Portillo J, Yu J, Vos S, Bapputty R, Lopez Corcino Y, Hubal A, et al.
Diabetologia
. 2022 Aug;
65(12):2157-2171.
PMID: 35920844
Aims/hypothesis: CD40 expressed in Müller cells is a central driver of diabetic retinopathy. CD40 causes phospholipase Cγ1 (PLCγ1)-dependent ATP release in Müller cells followed by purinergic receptor (P2X)-dependent production of...
8.
Yu J, Daw J, Portillo J, Subauste C
Invest Ophthalmol Vis Sci
. 2021 Sep;
62(12):22.
PMID: 34546322
Purpose: CD40 is an upstream inducer of inflammation in the diabetic retina. CD40 is upregulated in retinal endothelial cells in diabetes. The purpose of this study was to determine whether...
9.
Subauste C
Front Cell Dev Biol
. 2021 Jun;
9:673813.
PMID: 34179003
is an obligate intracellular protozoan that can cause encephalitis and retinitis in humans. The success of as a pathogen depends in part on its ability to form an intracellular niche...
10.
Portillo J, Yu J, Hansen S, Kern T, Subauste M, Subauste C
FASEB J
. 2021 Mar;
35(3):e21412.
PMID: 33675257
While the administration of anti-CD154 mAbs in mice validated the CD40-CD154 pathway as a target against inflammatory disorders, this approach caused thromboembolism in humans (unrelated to CD40 inhibition) and is...