Jose-Andres C Portillo
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Explore the profile of Jose-Andres C Portillo including associated specialties, affiliations and a list of published articles.
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27
Citations
648
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Recent Articles
11.
Portillo J, Lopez Corcino Y, Dubyak G, Kern T, Matsuyama S, Subauste C
Invest Ophthalmol Vis Sci
. 2016 Nov;
57(14):6278-6286.
PMID: 27893093
Purpose: Cluster of differentiation 40 (CD40) is required for retinal capillary degeneration in diabetic mice, a process mediated by the retinal endothelial cells (REC) death. However, CD40 activates prosurvival signals...
12.
Portillo J, Lopez Corcino Y, Miao Y, Tang J, Sheibani N, Kern T, et al.
Diabetes
. 2016 Jul;
66(2):483-493.
PMID: 27474370
Müller cells and macrophages/microglia are likely important for the development of diabetic retinopathy; however, the interplay between these cells in this disease is not well understood. An inflammatory process is...
13.
Liu E, Lopez Corcino Y, Portillo J, Miao Y, Subauste C
Infect Immun
. 2016 Jun;
84(9):2616-26.
PMID: 27354443
CD40 is an important stimulator of autophagy and autophagic killing of Toxoplasma gondii in host cells. In contrast to autophagy induced by nutrient deprivation or pattern recognition receptors, less is...
14.
Greene J, Portillo J, Lopez Corcino Y, Subauste C
PLoS One
. 2015 Dec;
10(12):e0144133.
PMID: 26710229
CD40, CX3CL1 and TNF-α promote atheroma and neointima formation. CD40 and TNF-α are also central to the development of diabetic retinopathy while CX3CL1 may play a role in the pathogenesis...
15.
Portillo J, Schwartz I, Zarini S, Bapputty R, Kern T, Gubitosi-Klug R, et al.
Invest Ophthalmol Vis Sci
. 2014 Dec;
55(12):8590-7.
PMID: 25477319
Purpose: The cell surface receptor CD40 is required for the development of retinopathies induced by diabetes and ischemia/reperfusion. The purpose of this study was to identify signaling pathways by which...
16.
Portillo J, Greene J, Schwartz I, Subauste M, Subauste C
Immunology
. 2014 Jul;
144(1):21-33.
PMID: 25051892
Inhibition of the CD40-CD154 pathway controls inflammatory disorders. Unfortunately, administration of anti-CD154 monoclonal antibodies causes thromboembolism. Blockade of signalling downstream of CD40 may represent an approach to treat CD40-driven inflammatory...
17.
Portillo J, Greene J, Okenka G, Miao Y, Sheibani N, Kern T, et al.
Diabetologia
. 2014 Jul;
57(10):2222-31.
PMID: 25015056
Aims/hypothesis: Microangiopathy is a leading complication of diabetes that commonly affects the retina. Degenerate capillaries are a central feature of diabetic retinopathy. An inflammatory process has been linked to the...
18.
Muniz-Feliciano L, Van Grol J, Portillo J, Liew L, Liu B, Carlin C, et al.
PLoS Pathog
. 2013 Dec;
9(12):e1003809.
PMID: 24367261
Toxoplasma gondii resides in an intracellular compartment (parasitophorous vacuole) that excludes transmembrane molecules required for endosome-lysosome recruitment. Thus, the parasite survives by avoiding lysosomal degradation. However, autophagy can re-route the...
19.
Cheng L, Bu H, Portillo J, Li Y, Subauste C, Huang S, et al.
Invest Ophthalmol Vis Sci
. 2013 Nov;
54(13):8191-8.
PMID: 24265019
Purpose: Müller cells, a major type of glial cell found in the eye, are postulated to play an important role in many retinal diseases, including diabetic retinopathy (DR). Complement is...
20.
Ogolla P, Portillo J, White C, Patel K, Lamb B, Sen G, et al.
PLoS Pathog
. 2013 Aug;
9(8):e1003557.
PMID: 23990781
PKR is well characterized for its function in antiviral immunity. Using Toxoplasma gondii, we examined if PKR promotes resistance to disease caused by a non-viral pathogen. PKR(-/-) mice infected with...