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Jorn Coers

Explore the profile of Jorn Coers including associated specialties, affiliations and a list of published articles. Areas
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Articles 74
Citations 5397
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Recent Articles
1.
Fee B, Fee L, Menechella M, Affeldt B, Sprouse A, Bounini A, et al.
J Biol Chem . 2024 Oct; 300(11):107883. PMID: 39395806
The human IRGM gene has been linked to inflammatory diseases including sepsis and Crohn's disease. Decreased expression of human IRGM, or the mouse orthologues Irgm1 and Irgm2, leads to increased...
2.
Saavedra-Sanchez L, Dickinson M, Apte S, Zhang Y, de Jong M, Skavicus S, et al.
bioRxiv . 2024 Sep; PMID: 39282383
A central signal that marshals host defense against many infections is the lymphocyte-derived cytokine interferon-gamma (IFNγ). The IFNγ receptor is expressed on most human cells and its activation leads to...
3.
Reitano J, Coers J
Pathog Dis . 2024 Aug; 82. PMID: 39210512
Chlamydia trachomatis is the most common cause of bacterial sexually transmitted infection (STI) in the USA. As an STI, C. trachomatis infections can cause inflammatory damage to the female reproductive...
4.
Dockterman J, Reitano J, Everitt J, Wallace G, Hendrix M, Taylor G, et al.
mBio . 2024 Mar; 15(4):e0030324. PMID: 38501887
Importance: In response to genital Chlamydia infection, the immune system mounts a proinflammatory response to resist the pathogen, yet inflammation must be tightly controlled to avoid collateral damage and scarring...
5.
Bastidas R, Kedzior M, Davidson R, Walsh S, Dolat L, Sixt B, et al.
Elife . 2024 Feb; 12. PMID: 38358795
Many cellular processes are regulated by ubiquitin-mediated proteasomal degradation. Pathogens can regulate eukaryotic proteolysis through the delivery of proteins with de-ubiquitinating (DUB) activities. The obligate intracellular pathogen secretes Cdu1 (ChlaDUB1),...
6.
Abele T, Billman Z, Harvest C, Bryan A, Larson H, Coers J, et al.
Infect Immun . 2023 Dec; 92(1):e0032923. PMID: 38084951
Engineering pathogens is a useful method for discovering new details of microbial pathogenesis and host defense. However, engineering can result in off-target effects. We previously engineered serovar Typhimurium to overexpress...
7.
Kirchner S, Lei V, Kim P, Patel M, Shannon J, Corcoran D, et al.
JCI Insight . 2023 Sep; 8(20. PMID: 37725438
Aged skin is prone to viral infections, but the mechanisms responsible for this immunosenescent immune risk are unclear. We observed that aged murine and human skin expressed reduced levels of...
8.
Huang H, Xue Y, Jewell M, Tan C, Theriot B, Aggarwal N, et al.
Cell Rep . 2023 Sep; 42(9):113143. PMID: 37682708
No abstract available.
9.
Huang H, Xue Y, Jewell M, Tan C, Theriot B, Aggarwal N, et al.
Cell Rep . 2023 Aug; 42(8):112951. PMID: 37556321
Little is known about how microbiota regulate innate-like γδ T cells or how these restrict their effector functions within mucosal barriers, where microbiota provide chronic stimulation. Here, we show that...
10.
Li L, Dickinson M, Coers J, Miao E
Semin Immunol . 2023 Jul; 69:101805. PMID: 37429234
Pathogenic microbes invade the human body and trigger a host immune response to defend against the infection. In response, host-adapted pathogens employ numerous virulence strategies to overcome host defense mechanisms....