Jorgen F P Wojtaszewski
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Explore the profile of Jorgen F P Wojtaszewski including associated specialties, affiliations and a list of published articles.
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196
Citations
6978
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Recent Articles
1.
Li J, Madsen A, Knudsen J, Henriquez-Olguin C, Persson K, Li Z, et al.
FASEB J
. 2025 Jan;
39(2):e70277.
PMID: 39835637
The kinases AMPK, and mTOR as part of either mTORC1 or mTORC2, are major orchestrators of cellular growth and metabolism. Phosphorylation of mTOR Ser1261 is reportedly stimulated by both insulin...
2.
She R, Suvitaival T, Andersen H, Hommel E, Norgaard K, Wojtaszewski J, et al.
J Clin Endocrinol Metab
. 2025 Jan;
PMID: 39829147
Introduction: Metabolic responses to glucagon beyond the promotion of endogenous glucose production in type 1 diabetes remains poorly explored. Therefore, we aimed to investigate the metabolic responses to glucagon stimulation...
3.
Kolnes K, Nilsen E, Brufladt S, Meadows A, Jeppesen P, Skattebo O, et al.
Nat Commun
. 2025 Jan;
16(1):122.
PMID: 39747857
Humans have, throughout history, faced periods of starvation necessitating increased physical effort to gather food. To explore adaptations in muscle function, 13 participants (7 males and 6 females) fasted for...
4.
Needham E, Hingst J, Onslev J, Diaz-Vegas A, Leandersson M, Huckstep H, et al.
Cell Metab
. 2024 Nov;
36(12):2542-2559.e6.
PMID: 39577414
Type 2 diabetes is preceded by a defective insulin response, yet our knowledge of the precise mechanisms is incomplete. Here, we investigate how insulin resistance alters skeletal muscle signaling and...
5.
Kristensen J, Kjobsted R, Larsen T, Carl C, Hingst J, Onslev J, et al.
Nat Metab
. 2024 Nov;
6(12):2254-2266.
PMID: 39482542
In the Greenlandic Inuit population, 4% are homozygous carriers of a genetic nonsense TBC1D4 p.Arg684Ter variant leading to loss of the muscle-specific isoform of TBC1D4 and an approximately tenfold increased...
6.
Fiorenza M, Onslev J, Henriquez-Olguin C, Persson K, Hesselager S, Jensen T, et al.
Sci Adv
. 2024 Oct;
10(44):eadq4461.
PMID: 39475607
Preclinical models suggest mitochondria-derived oxidative stress as an underlying cause of insulin resistance. However, it remains unknown whether this pathophysiological mechanism is conserved in humans. Here, we used an invasive...
7.
Hjorth M, Egan C, Telles G, Pal M, Gallego-Ortega D, Fuller O, et al.
J Sport Health Sci
. 2024 Sep;
14:100991.
PMID: 39341495
Purpose: Regular exercise can reduce incidence and progression of breast cancer, but the mechanisms for such effects are not fully understood. The purpose of this study was to examine the...
8.
Eskesen N, Kjobsted R, Birk J, Henriksen N, Andersen N, Ringholm S, et al.
Acta Physiol (Oxf)
. 2024 Aug;
240(10):e14213.
PMID: 39171449
Aim: AMP-activated protein kinase (AMPK) is activated during cellular energy perturbation. AMPK complexes are composed of three subunits and several variants of AMPK are expressed in skeletal muscle. The regulatory...
9.
Onslev J, Fiorenza M, Thomassen M, Havelund J, Bangsbo J, Faergeman N, et al.
J Clin Endocrinol Metab
. 2024 May;
110(1):275-288.
PMID: 38820114
Context: Given the promising effects of prolonged treatment with beta2-agonist on insulin sensitivity in animals and nondiabetic individuals, the beta2-adrenergic receptor has been proposed as a target to counter peripheral...
10.
Voldstedlund C, Sjoberg K, Schlabs F, Sigvardsen C, Andersen N, Holst J, et al.
Diabetologia
. 2024 Apr;
67(7):1386-1398.
PMID: 38662135
Aims/hypothesis: Exercise has a profound effect on insulin sensitivity in skeletal muscle. The euglycaemic-hyperinsulinaemic clamp (EHC) is the gold standard for assessment of insulin sensitivity but it does not reflect...