Jorge Vialard
Overview
Explore the profile of Jorge Vialard including associated specialties, affiliations and a list of published articles.
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Articles
11
Citations
513
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0
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Recent Articles
1.
Wang W, Mevellec L, Liu A, Struble G, Miller R, Allen S, et al.
Biochemistry
. 2021 Oct;
60(41):3114-3124.
PMID: 34608799
Achieving selectivity across the human kinome is a major hurdle in kinase inhibitor drug discovery. Assays using active, phosphorylated protein kinases bias hits toward poorly selective inhibitors that bind within...
2.
Simm J, Klambauer G, Arany A, Steijaert M, Wegner J, Gustin E, et al.
Cell Chem Biol
. 2018 Mar;
25(5):611-618.e3.
PMID: 29503208
In both academia and the pharmaceutical industry, large-scale assays for drug discovery are expensive and often impractical, particularly for the increasingly important physiologically relevant model systems that require primary cells,...
3.
Perera T, Jovcheva E, Mevellec L, Vialard J, De Lange D, Verhulst T, et al.
Mol Cancer Ther
. 2017 Mar;
16(6):1010-1020.
PMID: 28341788
Fibroblast growth factor (FGF) signaling plays critical roles in key biological processes ranging from embryogenesis to wound healing and has strong links to several hallmarks of cancer. Genetic alterations in...
4.
Lupo B, Vialard J, Sassi F, Angibaud P, Puliafito A, Pupo E, et al.
BMC Biol
. 2016 Jan;
14:5.
PMID: 26787475
Background: Tankyrases are poly(adenosine diphosphate)-ribose polymerases that contribute to biological processes as diverse as modulation of Wnt signaling, telomere maintenance, vesicle trafficking, and microtubule-dependent spindle pole assembly during mitosis. At...
5.
Lambertz I, Kumps C, Claeys S, Lindner S, Beckers A, Janssens E, et al.
Clin Cancer Res
. 2015 Mar;
21(14):3327-39.
PMID: 25805801
Purpose: Activating ALK mutations are present in almost 10% of primary neuroblastomas and mark patients for treatment with small-molecule ALK inhibitors in clinical trials. However, recent studies have shown that...
6.
Cargnelutti M, Corso S, Pergolizzi M, Mevellec L, Aisner D, Dziadziuszko R, et al.
Oncotarget
. 2015 Feb;
6(7):5182-94.
PMID: 25691052
The ROS1 tyrosine kinase is activated in lung cancer as a consequence of chromosomal rearrangement. Although high response rates and disease control have been observed in lung cancer patients bearing...
7.
Jenkins Y, Markovtsov V, Lang W, Sharma P, Pearsall D, Warner J, et al.
Mol Biol Cell
. 2005 Oct;
16(12):5621-9.
PMID: 16195352
Early cellular events associated with tumorigenesis often include loss of cell cycle checkpoints or alteration in growth signaling pathways. Identification of novel genes involved in cellular proliferation may lead to...
8.
Dendouga N, Gao H, Moechars D, Janicot M, Vialard J, McGowan C
Mol Cell Biol
. 2005 Aug;
25(17):7569-79.
PMID: 16107704
The Mus81-Eme1 endonuclease is implicated in the efficient rescue of broken replication forks in Saccharomyces cerevisiae and Schizosaccharomyces pombe. We have used gene targeting to study the function of the...
9.
De Ketelaere A, Vermeulen L, Vialard J, van de Weyer I, Wauwe J, Haegeman G, et al.
FEBS Lett
. 2004 May;
566(1-3):60-4.
PMID: 15147869
Glycogen synthase kinase-3beta (GSK-3beta) is a key component of several signaling pathways. We found that a short variant of 'TNF-like weak inducer of apoptosis' (shortTWEAK) formed a complex with GSK-3beta...
10.
Hitoshi Y, Gururaja T, Pearsall D, Lang W, Sharma P, Huang B, et al.
Chem Biol
. 2003 Oct;
10(10):975-87.
PMID: 14583264
No abstract available.