Jorge Busciglio
Overview
Explore the profile of Jorge Busciglio including associated specialties, affiliations and a list of published articles.
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38
Citations
1599
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Recent Articles
11.
Torres M, Garcia O, Tang C, Busciglio J
Free Radic Biol Med
. 2017 Oct;
114:10-14.
PMID: 28965914
Abnormal dendritic spine structure and function is one of the most prominent features associated with neurodevelopmental disorders including Down syndrome (DS). Defects in both spine morphology and spine density may...
12.
Delabar J, Allinquant B, Bianchi D, Blumenthal T, Dekker A, Edgin J, et al.
Mol Syndromol
. 2016 Nov;
7(5):251-261.
PMID: 27867340
Down syndrome (DS) is the most common genetic cause of intellectual disability (ID) in humans with an incidence of ∼1:1,000 live births worldwide. It is caused by the presence of...
13.
Coskun P, Helguera P, Nemati Z, Bohannan R, Thomas J, Samuel S, et al.
J Alzheimers Dis
. 2016 Nov;
55(2):737-748.
PMID: 27802222
Background: Deficits in mitochondrial function and oxidative stress play pivotal roles in Down syndrome (DS) and Alzheimer's disease (AD) and these alterations in mitochondria occur systemically in both conditions. Objective:...
14.
Peiris H, Duffield M, Fadista J, Jessup C, Kashmir V, Genders A, et al.
PLoS Genet
. 2016 May;
12(5):e1006033.
PMID: 27195491
Type 2 diabetes (T2D) is a complex metabolic disease associated with obesity, insulin resistance and hypoinsulinemia due to pancreatic β-cell dysfunction. Reduced mitochondrial function is thought to be central to...
15.
Iulita M, Do Carmo S, Ower A, Fortress A, Aguilar L, Hanna M, et al.
Brain
. 2014 Feb;
137(Pt 3):860-72.
PMID: 24519975
Basal forebrain cholinergic neurons play a key role in cognition. This neuronal system is highly dependent on NGF for its synaptic integrity and the phenotypic maintenance of its cell bodies....
16.
Sosa L, Postma N, Estrada-Bernal A, Hanna M, Guo R, Busciglio J, et al.
FASEB J
. 2013 Sep;
28(1):195-205.
PMID: 24036883
Amyloid precursor protein (APP), encoded on Hsa21, functions as a cell adhesion molecule (CAM) in axonal growth cones (GCs) of the developing brain. We show here that axonal GCs of...
17.
Vogler E, Busciglio J
Curr Pharm Des
. 2013 Jul;
20(15):2520-4.
PMID: 23859544
So far, therapeutics focusing on reducing levels of amyloid beta for treatment of Alzheimer's disease have not been successful in completing clinical trials to come to market, suggesting the need...
18.
Yeo M, Berglund K, Hanna M, Guo J, Kittur J, Torres M, et al.
Proc Natl Acad Sci U S A
. 2013 Feb;
110(11):4315-20.
PMID: 23440186
Bisphenol A (BPA) is a ubiquitous compound that is emerging as a possible toxicant during embryonic development. BPA has been shown to epigenetically affect the developing nervous system, but the...
19.
Helguera P, Seiglie J, Rodriguez J, Hanna M, Helguera G, Busciglio J
Cell Metab
. 2013 Jan;
17(1):132-40.
PMID: 23312288
Mitochondrial dysfunction and oxidative stress are common features of Down syndrome (DS). However, the underlying mechanisms are not known. We investigated the relationship between abnormal energy metabolism and oxidative stress...
20.
Coskun P, Busciglio J
Curr Gerontol Geriatr Res
. 2012 May;
2012:383170.
PMID: 22611387
Genome-wide gene deregulation and oxidative stress appear to be critical factors determining the high variability of phenotypes in Down's syndrome (DS). Even though individuals with trisomy 21 exhibit a higher...