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Jorge Becerril

Explore the profile of Jorge Becerril including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 8
Citations 210
Followers 0
Related Specialties
Chemistry
Biochemistry
Top 10 Co-Authors
Andrew D Hamilton
Juan F Miravet
M Isabel Burguete
Santiago V Luis
Hang Yin
Beatriu Escuder
Francisco Galindo
Gabriel Peris
Jie Wu
James S Panek
Published In
Angew Chem Int Ed Engl
Chem Commun (Camb)
Chemistry
J Biol Chem
J Am Chem Soc
Affiliations
Soon will be listed here.
Recent Articles
1.
Sequential transformations to access polycyclic chemotypes: asymmetric crotylation and metal carbenoid reactions
Wu J, Becerril J, Lian Y, Davies H, Porco Jr J, Panek J
Angew Chem Int Ed Engl . 2011 May; 50(26):5938-42. PMID: 21560214
No abstract available.
2.
The BH3 alpha-helical mimic BH3-M6 disrupts Bcl-X(L), Bcl-2, and MCL-1 protein-protein interactions with Bax, Bak, Bad, or Bim and induces apoptosis in a Bax- and Bim-dependent manner
Kazi A, Sun J, Doi K, Sung S, Takahashi Y, Yin H, et al.
J Biol Chem . 2010 Dec; 286(11):9382-92. PMID: 21148306
A critical hallmark of cancer cell survival is evasion of apoptosis. This is commonly due to overexpression of anti-apoptotic proteins such as Bcl-2, Bcl-X(L), and Mcl-1, which bind to the...
3.
Synthetic alpha-helix mimetics as agonists and antagonists of islet amyloid polypeptide aggregation
Saraogi I, Hebda J, Becerril J, Estroff L, Miranker A, Hamilton A
Angew Chem Int Ed Engl . 2009 Dec; 49(4):736-9. PMID: 20029853
No abstract available.
4.
Helix mimetics as inhibitors of the interaction of the estrogen receptor with coactivator peptides
Becerril J, Hamilton A
Angew Chem Int Ed Engl . 2007 May; 46(24):4471-3. PMID: 17487924
No abstract available.
5.
Self-assembly of small peptidomimetic cyclophanes
Becerril J, Isabel Burguete M, Escuder B, Galindo F, Gavara R, Miravet J, et al.
Chemistry . 2004 Aug; 10(16):3879-90. PMID: 15316991
The self-assembly of a series of small peptidomimetic cyclophanes in organic solvents was studied. X-ray diffraction, NMR spectroscopy, and molecular modelling were used to understand the structural features of these...
6.
Efficient macrocyclization of U-turn preorganized peptidomimetics: the role of intramolecular H-bond and solvophobic effects
Becerril J, Bolte M, Isabel Burguete M, Galindo F, Garcia-Espana E, Luis S, et al.
J Am Chem Soc . 2003 May; 125(22):6677-86. PMID: 12769577
Simple peptidomimetic molecules derived from amino acids were reacted with meta- and para-bis(bromomethyl)benzene in acetonitrile to very efficiently yield macrocyclic structures. The cyclization reaction does not require high dilution techniques...
7.
Design and application of an alpha-helix-mimetic scaffold based on an oligoamide-foldamer strategy: antagonism of the Bak BH3/Bcl-xL complex
Ernst J, Becerril J, Park H, Yin H, Hamilton A
Angew Chem Int Ed Engl . 2003 Feb; 42(5):535-9. PMID: 12569483
No abstract available.
8.
Minimalist peptidomimetic cyclophanes as strong organogelators
Becerril J, Isabel Burguete M, Escuder B, Luis S, Miravet J, Querol M
Chem Commun (Camb) . 2002 Jul; (7):738-9. PMID: 12119699
L-Valine containing cyclophanes have been shown to gelate organic solvents leading to soft materials with a clear expression of their chirality at the supramolecular level.