Jorg Volkland
Overview
Explore the profile of Jorg Volkland including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
292
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Recent Articles
1.
Munz M, Murr A, Kvesic M, Rau D, Mangold S, Pflanz S, et al.
Cancer Cell Int
. 2010 Nov;
10:44.
PMID: 21044305
Background: Epithelial cell adhesion molecule (EpCAM) is frequently and highly expressed on human carcinomas. The emerging role of EpCAM as a signalling receptor and activator of the wnt pathway, and...
2.
Steigerwald J, Raum T, Pflanz S, Cierpka R, Mangold S, Rau D, et al.
MAbs
. 2010 Jan;
1(2):115-27.
PMID: 20061825
NKG2D is a surface receptor expressed on NK cells but also on CD8(+) T cells, gammadelta T cells, and auto-reactive CD4(+)/CD28(-) T cells of patients with rheumatoid arthritis. Various studies...
3.
Amann M, dArgouges S, Lorenczewski G, Brischwein K, Kischel R, Lutterbuese R, et al.
J Immunother
. 2009 Jul;
32(5):452-64.
PMID: 19609237
muS110 is a BiTE antibody bispecific for murine EpCAM (CD326) and murine CD3. MT110, its human-specific analog, is in a clinical phase 1 trial for treatment of patients with adenocarcinoma...
4.
Brischwein K, Parr L, Pflanz S, Volkland J, Lumsden J, Klinger M, et al.
J Immunother
. 2007 Dec;
30(8):798-807.
PMID: 18049331
Bispecific antibodies have been extensively studied in vitro and in vivo for their use in redirected tumor cell lysis. A particular challenge of bispecific antibody constructs that recognize the invariant...
5.
Volkland J, Lumsden J, Molhoj M, Raum T, Hausmann S, Wissing S, et al.
Mol Immunol
. 2006 Sep;
44(7):1743-53.
PMID: 17000002
Inhibition of the interleukin-2 (IL-2) pathway has potent immunosuppressive activity in humans as is evident from the broad therapeutic utility of cyclosporine, rapamycin, tacrolimus, and monoclonal antibodies blocking the high-affinity...
6.
Krinner E, Hepp J, Hoffmann P, Bruckmaier S, Petersen L, Petsch S, et al.
Protein Eng Des Sel
. 2006 Jul;
19(10):461-70.
PMID: 16868004
GM-CSF (granulocyte-macrophage colony stimulating factor) plays a central role in inflammatory processes. Treatment with antibodies neutralizing murine GM-CSF showed significant therapeutic effects in mouse models of inflammatory diseases. We constructed...
7.
Alappat E, Feig C, Boyerinas B, Volkland J, Samuels M, Murmann A, et al.
Mol Cell
. 2005 Aug;
19(3):321-32.
PMID: 16061179
FADD is essential for death receptor (DR)-induced apoptosis. However, it is also critical for cell cycle progression and proliferation, activities that are regulated by phosphorylation of its C-terminal Ser194, which...
8.
Alappat E, Volkland J, Peter M
J Biol Chem
. 2003 Sep;
278(43):41585-8.
PMID: 12954630
Expression of a truncated form of the death receptor adaptor FADD (C-FADD) as a transgene in mice blocks T cell proliferation. Here we provide evidence that the C-terminal phosphorylation site...
9.
Stegh A, Barnhart B, Volkland J, Algeciras-Schimnich A, Ke N, Reed J, et al.
J Biol Chem
. 2001 Dec;
277(6):4351-60.
PMID: 11733517
Apoptosis induction through CD95 (APO-1/Fas) critically depends on generation of active caspase-8 at the death-inducing signaling complex (DISC). Depending on the cell type, active caspase-8 either directly activates caspase-3 (type...