Doris Rau
Overview
Explore the profile of Doris Rau including associated specialties, affiliations and a list of published articles.
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11
Citations
346
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Recent Articles
1.
Harmalkar A, Rao R, Xie Y, Honer J, Deisting W, Anlahr J, et al.
MAbs
. 2023 Jan;
15(1):2163584.
PMID: 36683173
Over the last three decades, the appeal for monoclonal antibodies (mAbs) as therapeutics has been steadily increasing as evident with FDA's recent landmark approval of the 100th mAb. Unlike mAbs...
2.
Deegen P, Thomas O, Nolan-Stevaux O, Li S, Wahl J, Bogner P, et al.
Clin Cancer Res
. 2021 Jan;
27(10):2928-2937.
PMID: 33504551
Purpose: Metastatic castration-resistant prostate cancer (mCRPC) remains a disease with high unmet medical need, as most patients do not achieve durable response with available treatments. Prostate-specific membrane antigen (PSMA) is...
3.
Friedrich M, Raum T, Lutterbuese R, Voelkel M, Deegen P, Rau D, et al.
Mol Cancer Ther
. 2012 Oct;
11(12):2664-73.
PMID: 23041545
For treatment of patients with prostate cancer (PCa), we developed a novel T cell-engaging (BiTE) antibody designated AMG 212 or BAY2010112 that is bispecific for prostate-specific membrane antigen (PSMA) and...
4.
Munz M, Murr A, Kvesic M, Rau D, Mangold S, Pflanz S, et al.
Cancer Cell Int
. 2010 Nov;
10:44.
PMID: 21044305
Background: Epithelial cell adhesion molecule (EpCAM) is frequently and highly expressed on human carcinomas. The emerging role of EpCAM as a signalling receptor and activator of the wnt pathway, and...
5.
Lutterbuese R, Raum T, Kischel R, Hoffmann P, Mangold S, Rattel B, et al.
Proc Natl Acad Sci U S A
. 2010 Jul;
107(28):12605-10.
PMID: 20616015
Epidermal growth factor receptor (EGFR)-specific monoclonal antibodies predominantly inhibit colorectal cancer (CRC) growth by interfering with receptor signaling. Recent analyses have shown that patients with CRC with mutated KRAS and...
6.
Steigerwald J, Raum T, Pflanz S, Cierpka R, Mangold S, Rau D, et al.
MAbs
. 2010 Jan;
1(2):115-27.
PMID: 20061825
NKG2D is a surface receptor expressed on NK cells but also on CD8(+) T cells, gammadelta T cells, and auto-reactive CD4(+)/CD28(-) T cells of patients with rheumatoid arthritis. Various studies...
7.
Amann M, dArgouges S, Lorenczewski G, Brischwein K, Kischel R, Lutterbuese R, et al.
J Immunother
. 2009 Jul;
32(5):452-64.
PMID: 19609237
muS110 is a BiTE antibody bispecific for murine EpCAM (CD326) and murine CD3. MT110, its human-specific analog, is in a clinical phase 1 trial for treatment of patients with adenocarcinoma...
8.
Lutterbuese R, Raum T, Kischel R, Lutterbuese P, Schlereth B, Schaller E, et al.
J Immunother
. 2009 Apr;
32(4):341-52.
PMID: 19342971
Carcinoembryonic antigen (CEA, CD66e) is a well-characterized tumor-associated antigen that is frequently overexpressed in tumors. Phospholipases release CEA from tumor cells resulting in high circulating serum levels of soluble CEA...
9.
Molhoj M, Crommer S, Brischwein K, Rau D, Sriskandarajah M, Hoffmann P, et al.
Mol Immunol
. 2006 Nov;
44(8):1935-43.
PMID: 17083975
Many kinds of bispecific antibodies recruiting T cells for cancer therapy have been developed. Side-by-side comparison has shown that CD19-/CD3-bispecific antibodies of the diabody, tandem diabody (Tandab) and quadroma format...
10.
Rau D, Kramer K, Hock B
J Immunoassay Immunochem
. 2002 May;
23(2):129-43.
PMID: 12033639
A system was constructed for the production of alkaline phosphatase (aP)-labeled antibody single-chain Fv (scFv) fragments in Escherichia coli. The expression vector pASK75 was modified by sequentially inserting the E....