Joren C Madsen
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Explore the profile of Joren C Madsen including associated specialties, affiliations and a list of published articles.
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131
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1928
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Recent Articles
1.
Kawai T, Williams W, Elias N, Fishman J, Crisalli K, Longchamp A, et al.
N Engl J Med
. 2025 Feb;
PMID: 39927618
Xenotransplantation offers a potential solution to the organ shortage crisis. A 62-year-old hemodialysis-dependent man with long-standing diabetes, advanced vasculopathy, and marked dialysis-access challenges received a gene-edited porcine kidney with 69...
2.
Tonsho M, O J, Ahrens K, Robinson K, Sommer W, Boskovic S, et al.
Sci Transl Med
. 2025 Jan;
17(782):eads0255.
PMID: 39841809
Long-term, immunosuppression-free allograft survival has been induced in human and nonhuman primate (NHP) kidney recipients after nonmyeloablative conditioning and donor bone marrow transplantation (DBMT), resulting in transient mixed hematopoietic chimerism....
3.
Chaban R, Ileka I, Kinoshita K, McGrath G, Habibabady Z, Ma M, et al.
Transplantation
. 2025 Jan;
PMID: 39792548
Background: Long-term renal allograft acceptance has been achieved in macaques using a transient mixed hematopoetic chimerism protocol, but similar regimens have proven unsuccessful in heart allograft recipients unless a kidney...
4.
Nawalaniec J, Landino S, O J, Miller C, Dehnadi A, Hanekamp I, et al.
Sci Rep
. 2024 Dec;
14(1):31930.
PMID: 39738516
The thymus is a rich source of regulatory T cells and plays a role in self-tolerance. Therefore, transplantation of a vascularized donor thymus may facilitate the induction of tolerance in...
5.
Landino S, Nawalaniec J, Hays N, Osho A, Keller B, Allan J, et al.
Am J Transplant
. 2024 Nov;
25(3):463-470.
PMID: 39551266
Induction immunosuppression in solid organ transplantation involves a short course of potent immunosuppression in the perioperative period, with the goal of preventing early acute rejection and delaying initiation or reducing...
6.
Zhou J, Sise M, Drezek K, Wolfe S, Osho A, Prario M, et al.
J Am Heart Assoc
. 2024 Oct;
13(20):e035443.
PMID: 39377217
Background: Transplantation using hearts obtained through donation after circulatory death (DCD) is increasing, but data on recipient renal outcomes are limited. Methods And Results: Patients at a single institution who...
7.
Cooper D, Riella L, Kawai T, Fishman J, Williams W, Elias N, et al.
Ann Surg
. 2024 Sep;
PMID: 39263749
In vitro studies indicate that kidney transplantation from gene-edited pigs in which expression of all three of the known glycan xenoantigens has been deleted may be more challenging in nonhuman...
8.
Jonkman I, Jacobs M, Negishi Y, Yanginlar C, Martens J, Baltissen M, et al.
Am J Transplant
. 2024 Aug;
24(11):2022-2033.
PMID: 39147201
The innate immune system plays an essential role in regulating the immune responses to kidney transplantation, but the mechanisms through which innate immune cells influence long-term graft survival are unclear....
9.
Yokose T, Szuter E, Rosales I, Guinn M, Liss A, Baba T, et al.
J Clin Invest
. 2024 Jun;
134(16).
PMID: 38888968
Tolerance of mouse kidney allografts arises in grafts that develop regulatory tertiary lymphoid organs (rTLOs). Single-cell RNA-seq (scRNA-seq) data and adoptive transfer of alloreactive T cells after transplantation showed that...
10.
Efe O, Gassen R, Morena L, Ganchiku Y, Al Jurdi A, Lape I, et al.
J Clin Invest
. 2024 Mar;
134(5).
PMID: 38426492
Long-term organ transplant survival remains suboptimal, and life-long immunosuppression predisposes transplant recipients to an increased risk of infection, malignancy, and kidney toxicity. Promoting the regulatory arm of the immune system...