Jordan E Otto
Overview
Explore the profile of Jordan E Otto including associated specialties, affiliations and a list of published articles.
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5
Citations
490
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Recent Articles
1.
Otto J, Ursu O, Wu A, Winter E, Cuoco M, Ma S, et al.
Mol Cell
. 2023 Apr;
83(8):1350-1367.e7.
PMID: 37028419
The mammalian SWI/SNF (mSWI/SNF or BAF) family of chromatin remodeling complexes play critical roles in regulating DNA accessibility and gene expression. The three final-form subcomplexes-cBAF, PBAF, and ncBAF-are distinct in...
2.
Celen C, Chuang J, Shen S, Li L, Maggiore G, Jia Y, et al.
Cell Rep
. 2022 Nov;
41(5):111581.
PMID: 36323264
The dynamic regulation of β-cell abundance is poorly understood. Since chromatin remodeling plays critical roles in liver regeneration, these mechanisms could be generally important for regeneration in other tissues. Here,...
3.
Xu G, Chhangawala S, Cocco E, Razavi P, Cai Y, Otto J, et al.
Nat Genet
. 2020 Jan;
52(2):198-207.
PMID: 31932695
Mutations in ARID1A, a subunit of the SWI/SNF chromatin remodeling complex, are the most common alterations of the SWI/SNF complex in estrogen-receptor-positive (ER) breast cancer. We identify that ARID1A inactivating...
4.
Mashtalir N, DAvino A, Michel B, Luo J, Pan J, Otto J, et al.
Cell
. 2018 Oct;
175(5):1272-1288.e20.
PMID: 30343899
Mammalian SWI/SNF (mSWI/SNF) ATP-dependent chromatin remodeling complexes are multi-subunit molecular machines that play vital roles in regulating genomic architecture and are frequently disrupted in human cancer and developmental disorders. To...
5.
Otto J, Kadoch C
Cancer Cell
. 2017 Nov;
32(5):542-543.
PMID: 29136498
In this issue of Cancer Cell, Sun et al. describe context-dependent oncogenic and tumor-suppressive functions for the mammalian SWI/SNF (BAF) complex subunit ARID1A in the development and progression of hepatocellular...