Jordan B Jastrab
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Explore the profile of Jordan B Jastrab including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
118
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0
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Recent Articles
1.
Jastrab J, Kagan J
Cell Chem Biol
. 2024 Apr;
31(5):835-850.
PMID: 38636521
Mammalian innate immunity is regulated by pattern-recognition receptors (PRRs) and guard proteins, which use distinct strategies to detect infections. PRRs detect bacterial molecules directly, whereas guards detect host cell manipulations...
2.
Becker S, Jastrab J, Dhabaria A, Chaton C, Rush J, Korotkov K, et al.
Proc Natl Acad Sci U S A
. 2019 Feb;
116(8):3202-3210.
PMID: 30723150
The human pathogen encodes a proteasome that carries out regulated degradation of bacterial proteins. It has been proposed that the proteasome contributes to nitrogen metabolism in , although this hypothesis...
3.
Hu K, Jastrab J, Zhang S, Kovach A, Zhao G, Darwin K, et al.
J Biol Chem
. 2018 Feb;
293(13):4713-4723.
PMID: 29414791
In all domains of life, proteasomes are gated, chambered proteases that require opening by activators to facilitate protein degradation. Twelve proteasome accessory factor E (PafE) monomers assemble into a single...
4.
Wu Y, Hu K, Li D, Bai L, Yang S, Jastrab J, et al.
Mol Microbiol
. 2017 Apr;
105(2):227-241.
PMID: 28419599
Mycobacterium tuberculosis (Mtb) has a proteasome system that is essential for its ability to cause lethal infections in mice. A key component of the system is the proteasomal adenosine triphosphatase...
5.
Bai L, Jastrab J, Isasa M, Hu K, Yu H, Gygi S, et al.
J Bacteriol
. 2017 Feb;
199(9).
PMID: 28193903
A previous bioinformatics analysis identified the proteins Rv2125 and Rv2714 as orthologs of the eukaryotic proteasome assembly chaperone 2 (PAC2). We set out to investigate whether Rv2125 or Rv2714 can...
6.
Jastrab J, Samanovic M, Copin R, Shopsin B, Darwin K
J Bacteriol
. 2017 Jan;
199(7).
PMID: 28096448
uses a proteasome to degrade proteins by both ATP-dependent and -independent pathways. While much has been learned about ATP-dependent degradation, relatively little is understood about the ATP-independent pathway, which is...
7.
Bai L, Hu K, Wang T, Jastrab J, Darwin K, Li H
Proc Natl Acad Sci U S A
. 2016 Mar;
113(14):E1983-92.
PMID: 27001842
The human pathogen Mycobacterium tuberculosis (Mtb) requires a proteasome system to cause lethal infections in mice. We recently found that proteasome accessory factor E (PafE, Rv3780) activates proteolysis by the...
8.
Jastrab J, Darwin K
Annu Rev Microbiol
. 2015 Oct;
69:109-27.
PMID: 26488274
Interest in bacterial proteasomes was sparked by the discovery that proteasomal degradation is required for the pathogenesis of Mycobacterium tuberculosis, one of the world's deadliest pathogens. Although bacterial proteasomes are...
9.
Jastrab J, Wang T, Murphy J, Bai L, Hu K, Merkx R, et al.
Proc Natl Acad Sci U S A
. 2015 Apr;
112(14):E1763-72.
PMID: 25831519
Mycobacterium tuberculosis encodes a proteasome that is highly similar to eukaryotic proteasomes and is required to cause lethal infections in animals. The only pathway known to target proteins for proteasomal...