Strategies of Bacterial Detection by Inflammasomes

Overview

Journal Cell Chem Biol

Publisher Cell Press

Specialty Biochemistry

Date 2024 Apr 18

PMID 38636521

Authors

Jordan B Jastrab

Jonathan C Kagan

Affiliations

Soon will be listed here.

Abstract

Mammalian innate immunity is regulated by pattern-recognition receptors (PRRs) and guard proteins, which use distinct strategies to detect infections. PRRs detect bacterial molecules directly, whereas guards detect host cell manipulations by microbial virulence factors. Despite sensing infection through different mechanisms, both classes of innate immune sensors can activate the inflammasome, an immune complex that can mediate cell death and inflammation. Inflammasome-mediated immune responses are crucial for host defense against many bacterial pathogens and prevent invasion by non-pathogenic organisms. In this review, we discuss the mechanisms by which inflammasomes are stimulated by PRRs and guards during bacterial infection, and the strategies used by virulent bacteria to evade inflammasome-mediated immunity.

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